Category: IIT JAM Biotechnology Previous Year Question paper Topic Animal biology

Category: IIT JAM Biotechnology Previous Year Question paper Topic Animal biology

IIT JAM Biotechnology Previous Year Question paper Topic Animal biology

46. Which of the following is(are) involved in the activation of cytotoxic T cells?  (A) MHC Class I molecules (B) Fc receptors (FcR) (C) T-cell receptor (TCR) (D) CTLA-4

Activation of Cytotoxic T Cells

45. In ABO blood group testing, which one of the following is INCORRECT?  (A) A group – agglutination with anti-A antibodies (B) B group – agglutination with anti-B antibodies (C) AB group – no agglutination with either anti-A or anti-B antibodies (D) O group – no agglutination with either anti-A or anti-B antibodies

ABO Blood Group Testing Explained

44. In humans, the testis temperature is maintained below the core body temperature with the help of: (A) Proximal tubule (B) Loop of Henle (C) Scrotum (D) Seminal vesicles

Why is the Scrotum Important for Testis Temperature?

43. T cells and B cells are:  (A) Lymphocytes (B) Erythrocytes (C) Epithelial cells (D) Squamous cells

T Cells and B Cells are Lymphocytes

42. Identify the INCORRECT statement about the immunoglobulins (Ig)  (A) IgM forms pentamer (B) IgA forms dimer (C) IgD is the most abundant immunoglobulin (D) IgE is associated with allergic reactions

Immunoglobulins (IgG, IgA, IgM, IgD, IgE)

41. Which of the following statements about antigen-antibody (Ag-Ab) complexes is (are) TRUE?  (A) Hydrogen bonds and van der Waals forces participate in Ag-Ab interactions (B) Ionic bonds and hydrophobic bonds participate in Ag-Ab interactions (C)The combined strengths of all interactions between a single antigen binding site on an antibody and a single epitope is called avidity (D) Antibody elicited by one antigen can cross react with an unrelated antigen.

Antigen-Antibody Interactions, Affinity and Avidity Explained

40. Determine the correctness or otherwise of the following Assertion [a] and Reason [r].  Assertion [a]. B cells secrete antibodies against a virus while cytotoxic T cells kill virus-infected cells. Reason [r]. B cells confer active immunity while cytotoxic T cells confer passive immunity. (A) [a] and [r] are true and [r] is the correct reason for [a] (B) [a] and [r] are true but [r] is not the correct reason for [a]  (C) [a] is true but [r] is false (D) [a] false but [r] is true

B Cells vs Cytotoxic T Cells

39. Which among the following contain(s) oxygen-rich blood in the human vascular system?  I. Right ventricle II. Aorta III. Pulmonary vein (A) I only          (B) I and II only (C) I, II and III   (D) II and III only

Oxygen-Rich Blood in Human Circulation

38. Identify the autoimmune diseases among the following  (A) Type II Diabetes Mellitus      (B) Type I Diabetes Mellitus (C) Gestational Diabetes (D) Pernicious Anaemia

Autoimmune Diseases

37.Higher levels of glycosylated hemoglobin (HbA1c) indicate                                   (A) high hemoglobin level          (B) anaemic condition (C) diabetes      (D) favism

HbA1c Indicates Diabetes

36. Match the entries in Group I with the entries in Group II  Group I                                          Group II Epilepsy                            1) Degeneration of neurons in cerebral cortex Alzheimer’s disease        2) Degeneration of dopamine releasing neurons Parkinson’s disease        3) Decreased production of acetylcholine Huntington’s disease      4) Defect in electric discharge in the neurons (A) P-3, Q-2, R-4, S-1 (B) P-4, Q-3, R-2, S-1 (C) P-4, Q-1, R-2, S-3 (D) P-1, Q-3, R-4, S-2

Match Neurological Disorders with Their Characteristics

35. The circulatory levels of estrogen is derived mainly from  (A) thecal and granulosa cells (B) gonadotrophs (C) endometrial epithelia (D) Leydig cells

Source of Circulating Estrogen

34. Eukaryotic cell containing flagella is  (A) cell lining the fallopian tube  (B) sperm (C) Paramecium (D) cell lining the respiratory tract

Eukaryotic Cells with Flagella

33. Pure IgG antibody was run on an SDS-PAGE under reducing condition. How many bands would you see after staining with Coomassie blue  (A) 4    (B) 2     (C) 1     (D) 6

Pure IgG on SDS-PAGE Under Reducing Conditions

32. Antigen and antibody interaction is shown by the following scheme Ab + Ag ⇌ Ab–Ag Where Ab is antibody, Ag is antigen and Ab-Ag is antigen-antibody complex. The values of k1 and k-1 are 5 × 10-5 pM-1s-1 and 2 × 107 s-1, respectively. The dissociation constant for the complex is             nM.

Antigen-Antibody Dissociation Constant (Kd) Calculation

31. Which of the following organs are correctly paired with their function?  (A) Large intestine — Protein digestion (B) Oral cavity — Starch digestion (C) Pancreas — Bile production (D) Small intestine — Fat digestion

Digestive Organs and Their Functions

30. The cells involved in allergic reactions and containing surface receptors of IgE antibodies and histamine are  (A) Basophils                (B) Mast cells    (C) Monocytes                (D) Neutrophils

Mast Cells and Allergic Reactions

29. The correct sequence of the following events in the human female reproductive cycle is  I: Secretion of FSH II: Growth of corpus luteum III: Growth of follicle and oogenesis IV: Ovulation V: Sudden increase in the levels of LH (A) I, II, IV, V, llI          (B) II, I, III, IV, V           (C) 1, III, V, IV, lI         (D) I, V, II I, IV, II

Human Female Reproductive Cycle Sequence Explained

28. The antigen binding site of an antibody is present  (A) at the constant region (B) at the C-terminal (C) at the variable region (D) between the constant and the variable region

Antigen Binding Site of an Antibody

27. A healthy individual has the cardiac output of 5.5 L and heart rate of 72 beats per minute. The stroke volume of the individual is ______mL.

Stroke Volume Formula and Calculation

26.  Antibody binds to antigen in solution through (A) ionic interactions.     (B) hydrogen bonds. (C) van der Waals interactions.    (D) hydrophobic interactions.

Antibody-Antigen Binding Forces Explained

25. Match the hormones in Group I with their functions in Group II  Group I                                                Group II P) Aldosterone                      1) Stimulates the synthesis and secretion of androgens from the testis Q) Luteinizing                      2) Helps in the re-absorption of Na+ and water from the kidney hormone (LH)                         R) Atrial natriuretic            3) Increases the heart rate and the strength of heart contraction. factor (ANF)      S) Epinephrine                     4) Causes dilation of blood vessels and reduction of blood pressure (A) P-2, Q-3, R-4, S-1    (B) P-2, Q-1, R-4, S-3 (C) P-1, Q-2, R-3, S-4     (D) P-3, Q-4, R-2, S-1

Match Hormones with Their Functions

24. Proenzyme pepsinogen is secreted from ‘P’ of gastric mucosa and converted into active enzyme pepsin on exposure to ‘Q’ secreted from ‘R’. Choose the CORRECT combination of P, Q and R. (A) P - chief cells Q - hydrochloric acid R –  oxyntic cells (B) P - parietal cells Q – enterokinase  R - chief cells (C) P - oxyntic cells Q - hydrochloric acid R – parietal cells (D) P - peptic cells Q – gastrin R - oxyntic cells

Pepsinogen Activation and Gastric Gland Cells

23. Which of the following feature(s) should be present in a protein to generate strong immune response (antibody production) in an animal? I. At least one B-cell epitope II. At least one T-cell epitope III. Proteolytic cleavage site(s) (A) I only          (B) II and III      (C) I and III       (D) I, II and III

Protein Features Required for Strong Immune Response

22. Which of the following cell types can develop from myeloid lineage?  (A) Macrophages           (B) T lymphocytes (C) B lymphocytes (D) Erythrocytes

Myeloid Lineage Cells Explained

21. Which of the following condition(s) lead(s) to reduced affinity of O₂ for human hemoglobin? (A) Reduction of pH of blood plasma from pH 7.4 to lower pH  (B) Decrease of partial pressure of CO₂ in the lungs from 6 to 2 kPa  (C) Enhancement of intracellular 2,3-bis phosphoglycerate (BPG) level from 5 to 8 mM  (D) Increase in ambient CO level from 1 to 600 ppm

Factors Affecting Oxygen Affinity of Hemoglobin

20. Match animals in Group I with major form of excreted nitrogen metabolite in Group II.  Group I Group II P. Bony fishes 1. Urea Q. Lions 2. Uric acid R. Birds 3. Ammonia (A) P-3, Q-1, R-2 (B) P-1, Q-2, R-3 (C) P-2, Q-3, R-1 (D) P-3, Q-2, R-1

Nitrogenous Waste Excretion in Animals

19. Which of the following cell types is infected by the human immunodeficiency virus-1?     (A) T-helper lymphocytes  (B) T-cytotoxic lymphocytes  (C) Plasma cells  (D) B-lymphocytes

HIV-1 Infection of T-Helper Lymphocytes

18. The receptors for gamma amino butyric acid (GABA) in humans are    (A) ligand gated chloride ion channels  (B) ligand gated sodium ion channels  (C) ligand gated potassium ion channels  (D) ligand gated calcium ion channels

GABA Receptors Explained

17. Which one of the following hormones is produced by the adrenal gland?   (A) Thyroxine  (B) Cortisol   (C) Insulin  (D) Melatonin

Cortisol Produced by Adrenal Gland

16. In chick embryo, the ectoderm generates  (A) alveolar cells (B) germ cells (C) neurons (D) red blood cells

Ectoderm Derivatives in Chick Embryo

15. Metabolic acidosis is associated with decreased plasma level of  (A) bicarbonate (B) lactate (C) oxygen (D) urea

Metabolic Acidosis and Plasma Bicarbonate Explained

14. Which one of the following is NOT used as a component in subunit vaccines?  (A) Capsular polysaccharide (B) Inactivated exotoxin (C) Inactivated virus (D) Viral glycoprotein

Subunit Vaccines Explained

13. Which one of the following statements about polyploidy is correct?  (A) Autopolyploids are derived from a single species (B) Autopolyploids are derived from two different species (C) Allopolyploids are derived from a single species (D) Allopolyploids are not fertile when mated with each other

Polyploidy Explained – Autopolyploid vs Allopolyploid

12. The correct hierarchy of taxa in the Linnaean classification of eukaryotes is  (A) kingdom, class, phylum, order, family, genus (B) kingdom, order, class, phylum, family, genus (C) kingdom, phylum, order, family, class, genus (D) kingdom, phylum, class, order, family, genus

Linnaean Classification Hierarchy

11. Hyperventilation (breathing rapidly and deeply) causes which of the following event(s) in the arterial blood?  (A) Decrease in CO₂ concentration (B) Decrease in proton concentration (C) Increase in pH (D) Increase in O₂ concentration

Effects of Hyperventilation on Arterial Blood

10. Class II MHC molecules are NOT expressed by (A) B-cells (B) dendritic cells (C) macrophages (D) T-cells

Class II MHC Molecules Are Not Expressed by T Cells

9. Determine the correctness or otherwise of the following Assertion [a] and Reason [r].  Assertion [a]: The cardiovascular organization called double circulation provides vigorous flow of blood to the brain, muscles, and other organs. Reason [r]: The blood is pumped a second time after it loses pressure in the capillary beds of the lungs or skin. (A) Both [a] and [r] are true and [r] is the correct reason for [a] (B) Both [a] and [r] are true but [r] is not the correct reason for [a] (C) Both [a] and [r] are false (D) [a] is true but [r] is false

Double Circulation in Humans

8. Which one of the following pairs of antibodies contains ‘J-chain’ in their multimeric form?  (A) IgA and IgE (B) IgA and IgM (C) IgD and IgE (D) IgD and IgG

J Chain in Immunoglobulins

7. In a nephron, _____ follows the ascending limb of the “loop of Henle”.  (A) Descending limb (B) Distal tubule (C) Collecting tubule (D) Proximal tubule

Distal Convoluted Tubule Follows the Ascending Limb

6. A rise in cytosolic calcium ion concentration just after fertilization in a sea urchin egg leads to  (A) Formation of fertilization envelope (B) Acrosomal reaction (C) Formation of vegetal pole (D) Formation of animal pole

Calcium Wave After Fertilization in Sea Urchin

5. Which of the following is involved in innate immune response in higher mammals?  (A) T cell antigen receptor (B) B cell antigen receptor (C) Toll-like receptor (D) Major histocompatibility complex-II molecule

Toll-Like Receptors (TLRs) in Innate Immunity

4. When the molecular weight of human immunoglobulin light chain is 24 kDa, the total molecular weight of human IgG is _____ kDa.

Molecular Weight of Human IgG – Immunoglobulin Structure

3. Presence of which one of the following in the urine indicates pregnancy in human?  (A) Progesterone (B)Follicle-stimulating hormone and luteinizing hormone (C) Estrogen (D) Human chorionic gonadotropin

Human Chorionic Gonadotropin Pregnancy Hormone

2. What is the role of bile salts in the mammalian digestive system?  (A) Bile salts convert pepsinogen to pepsin, and thus facilitate protein digestion. (B) Bile salts emulsify fat, and thus aid in fat digestion. (C) Bile salts are excretory products produced by the liver, and do not participate in digestion. (D) Bile salts facilitate digestion of all types of macromolecules in the small intestine.

Role of Bile Salts in the Mammalian Digestive System

1. The type of immunological protection provided by plasma therapy is  (A) Natural active (B) Natural passive (C) Artificial active (D) Artificial passive

Plasma Therapy and Artificial Passive Immunity

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