117. Which one of the following is the drug of choice for sexually transmitted disease caused by
Chlamydia trachomatis?
1. Ampicillin
2. Azithromycin
3. Ciprofloxacin
4. Metronidazole

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Explanation:

Chlamydia trachomatis is one of the most common causes of sexually transmitted infections (STIs) worldwide. It typically affects the urogenital tract and may be asymptomatic, especially in women, which can lead to complications like pelvic inflammatory disease (PID) or infertility if untreated.

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Recommended First-Line Treatment:

According to the CDC (Centers for Disease Control and Prevention) and WHO guidelines, the first-line drug of choice for uncomplicated genital chlamydial infections is:

• Azithromycin 1g orally in a single dose

OR

• Doxycycline 100 mg orally twice daily for 7 days

However, azithromycin is often preferred due to:

• Single-dose therapy (better patient compliance)

• Effective against urogenital and pharyngeal infections

• Safe for use in pregnancy

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Why Not the Other Options?

• Ampicillin: Not a recommended first-line therapy for Chlamydia; better suited for other infections.

• Ciprofloxacin: Primarily used for gonorrhea and other bacterial infections; not the best choice for Chlamydia.

• Metronidazole: Effective against anaerobic bacteria and protozoa (e.g., Trichomonas vaginalis, Bacterial Vaginosis), not Chlamydia.

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Final Answer:

2. Azithromycin

Let me know if you want a full comparison of STI treatments or a downloadable reference chart.