Q.73 Match List I with List II
| LIST I | LIST II |
|---|---|
| A. Angiotensin – II B. Dopamine C. Serotonin D. Endorphin | I. Control of body temperature II. Emotional response III. Stimulates thirst IV. Induces sleep |
Choose the correct answer from the options given below:
- A-IV, B-III, C-II, D-I
- A-II, B-III, C-IV, D-I
- A-III, B-II, C-IV, D-I
- A-I, B-II, C-III, D-IV
Correct Answer: A-III, B-I, C-IV, D-II
Angiotensin-II stimulates thirst via subfornical organ activation, dopamine controls body temperature through hypothalamic pathways, serotonin induces sleep regulation, and endorphins mediate emotional responses.
Option Analysis
A. Angiotensin-II – III. Stimulates thirst
True. This peptide hormone acts on circumventricular organs lacking blood-brain barrier to trigger drinking behavior and vasopressin release for water conservation.
B. Dopamine – I. Control of body temperature
True. Dopaminergic neurons in hypothalamus and preoptic area modulate thermoregulation; D2 receptor blockade causes hyperthermia while agonists induce hypothermia.
C. Serotonin – IV. Induces sleep
True. Serotonin from raphe nuclei promotes slow-wave sleep onset; selective serotonin reuptake inhibitors paradoxically improve sleep architecture despite initial insomnia.
D. Endorphin – II. Emotional response
True. These endogenous opioids bind mu receptors in limbic system, producing euphoria, reducing pain perception, and modulating stress responses during reward and emotion.
Incorrect Options Explained
-
A-IV, B-III, C-II, D-I: Wrong—Angiotensin-II thirst link broken; dopamine not primary thirst mediator.
-
A-II, B-III, C-IV, D-I: Wrong—Angiotensin-II not emotional; dopamine not thirst.
-
A-I, B-II, C-III, D-IV: Wrong—Angiotensin-II not temperature; serotonin not thirst.
Introduction to Neurotransmitter Functions Matching
Angiotensin II dopamine serotonin endorphin matching tests neuroendocrine regulation crucial for GATE Life Sciences, covering thirst, thermoregulation, sleep, and emotion. This analysis pairs each correctly with physiological roles.
Angiotensin-II Thirst Mechanism
Circulating Ang-II binds AT1 receptors on subfornical organ neurons, activating drinking via hypothalamic thirst centers and ADH secretion from posterior pituitary.
Dopamine in Body Temperature Regulation
Nigrostriatal and hypothalamic dopamine modulates preoptic thermosensitive neurons; antipsychotics disrupting D2 signaling cause neuroleptic malignant syndrome hyperthermia.
Serotonin Sleep Induction Pathway
Raphe serotonergic projections to sleep-promoting VLPO neurons facilitate NREM sleep; 5-HT2 receptors mediate REM suppression during early sleep cycles.
Endorphins and Emotional Processing
Beta-endorphin from arcuate nucleus activates mu-opioid receptors in amygdala and nucleus accumbens, generating reward feelings and dampening negative affect during stress.
Match List I List II Correct? Key Pathway A-III Angiotensin-II Thirst Yes SFO activation B-I Dopamine Temperature Yes Hypothalamic D2 C-IV Serotonin Sleep Yes Raphe-VLPO D-II Endorphin Emotion Yes Limbic mu-opioid -
