- In case of Hydra, the major head inducer of the hypostome organizer is a set of Wnt proteins acting through the canonical β- catenin pathway. What would be the result, if a transgenic Hydra is made to globally mis-express the downstream Wnt effector β- catenin?
(1) Ectopic buds will be formed all along the body axis and even on the top of the newly formed buds.
(2) Ectopic tentacles form at all levels.
(3) Both ectopic tentacles and buds would be formed along the body axis.
(4) There would be no change observe
The canonical Wnt/β-catenin pathway in Hydra governs the head organizer at the hypostome, acting as a key morphogenetic signal for regeneration and axis formation. Experimental overexpression of β-catenin downstream effectors allows researchers to study the effects on body patterning and morphogenesis.
Consequences of Global β-Catenin Overexpression
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Ectopic Bud Formation:
Over-activation or global mis-expression of β-catenin leads to multiple and misplaced organizer sites along the Hydra body column. -
Multiple Axes Development:
These ectopic organizers induce buds and secondary axes at various points, including on top of new buds, causing a branched morphology. -
Excess Head-Like Structures:
The elevated Wnt/β-catenin activity mimics head organizer function, resulting in repetitive head and bud formations. -
Experimental Corroboration:
Studies show transgenic Hydra lines with β-catenin overexpression develop branches or ectopic heads spaced naturally but distributed more abundantly than wild-type animals.
Explanation of Other Options
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Simple ectopic tentacles formation (option 2) is part of the phenotype but incomplete as the main effect includes ectopic buds and axes.
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Both ectopic tentacles and buds (option 3) is close but option 1 more fully captures the phenomenon of ectopic buds forming along the entire axis and on newly formed buds themselves.
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No change (option 4) is contradicted by extensive experimental evidence.
Summary
In transgenic Hydra with mis-expressed β-catenin, the organism shows ectopic buds all along the body axis and even atop newly formed buds, reflecting the powerful role of β-catenin in establishing organizers and driving regenerative growth.
Final Answer:
(1) Ectopic buds will be formed all along the body axis and even on the top of the newly formed buds. -
1 Comment
Kajal
November 18, 2025Option 1