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9. In an effort to produce gene knockout mice, a gene targeted homologous recombination was tried, with the exogenous. DNA containing neor gene (confer G-418 resistance) and tkHsv gene (confers […]

8. To generate a knock-in or a knock-out mouse, it is essential to use antibiotic selection to select the stem cells that have putatively integrated the construct accurately. Each construct […]

7. Following statements have been made about recombination in a diploid organism: A. Recombination could be identified by genotyping parents and offspring’s for a pair of loci. B. Recombination frequency […]

6. During an experiment, an Investigator found that the cell line used are RecA -/-.                  What could be the probable finding which led him to such observation? (1) Low of […]

5. A Holliday junction js a branched nucleic acid structure that contains four double stranded arms joined together. After strand invasion and branch migration the function must then be resolved […]

4. To obtain recombinant products during meiosis, a double-strand break in the DNA yields crossovers needed for chiasmata formation. The progression of the non-crossover and crossover pathways begins with the […]

3.Column X lists proteins that play a role in mediating DNA recombination processes and Column Y lists the possible functions of these proteins. Column X Proteins Column Y Functions A. […]

2. In Neurospora crasa tetrad analysis showed following result + : m :: 6 : 2. The phenomenon involved for above result would be (1) Branch migration      (2) Gene conversion […]

1. Holiday junction is observed during: (1) Mitosis               (2) Interphase (3) Recombination    (4) DNA damage The correct answer is: (3) Recombination. Holliday junction is a characteristic intermediate of homologous genetic recombination, especially during […]