127. Match the common antibody origin with appropriate generic name/brand name of the antibody
a Mouse i Binatumomab
b Chimeric ii Herceptin
c Humanized iii Pantimumab
d Human iv Retuxan
(1) a-ii, b-i, c-iv, d-iii
(2) a-i, b-iv, c-iii, d-ii
(3) a-i, b-iv, c-ii, d-iii
(4) a-iv, b-i, c-ii, d-iii
Detailed Explanation:
Question:
Match the common antibody origin with the appropriate generic name/brand name of the antibody.
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a Mouse
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b Chimeric
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c Humanized
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d Human
Antibody Brand/Generic Names:
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i Binatumomab
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ii Herceptin
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iii Pantimumab
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iv Rituxan
Answer Choices:
(1) a-ii, b-i, c-iv, d-iii
(2) a-i, b-iv, c-iii, d-ii
(3) a-i, b-iv, c-ii, d-iii
(4) a-iv, b-i, c-ii, d-iii
Correct Answer:
(3) a-i, b-iv, c-ii, d-iii
Explanation of Antibody Origins and Corresponding Brand Names:
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a. Mouse (i) Binatumomab:
Binatumomab is a bispecific T-cell engager monoclonal antibody that is mouse-origin. It is used in the treatment of relapsed or refractory acute lymphoblastic leukemia (ALL). -
b. Chimeric (iv) Rituxan:
Rituxan (generic name: rituximab) is a chimeric monoclonal antibody that is composed of both mouse and human components. It is used to treat various cancers like non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. -
c. Humanized (ii) Herceptin:
Herceptin (generic name: trastuzumab) is a humanized monoclonal antibody used in the treatment of HER2-positive breast cancer. It combines human and mouse components to reduce immune response and improve effectiveness. -
d. Human (iii) Pantimumab:
Pantimumab is a fully human monoclonal antibody and is used to treat colorectal cancer. Its origin is entirely human, making it the least likely to provoke immune responses in patients.
Conclusion:
Matching the origin of antibodies to their brand and generic names is crucial for understanding their composition and therapeutic uses. The right match helps clinicians select the appropriate therapy for patients based on antibody type, especially considering factors like immune responses and efficacy.
