Q.52 The lymphoid stem cells in the bone marrow form
(A). Natural killer cells
(B). Platelets
(C). B lymphocyte
(D). Neutrophils
1. (A) and (D).
2. (A) and (C).
3. (A) and (B).
4. (C) and (D).
Title: Lymphoid Stem Cells Bone Marrow Derivatives: B Cells & NK Cells (MCQ Solved)**
Lymphoid stem cells in bone marrow primarily form B lymphocytes and natural killer (NK) cells.
Correct Answer: 2. (A) and (C)
Common lymphoid progenitors (CLPs), derived from hematopoietic stem cells (HSCs) in bone marrow, differentiate into B cells (mature in marrow) and NK cells (migrate to periphery). T cells also originate from CLPs but mature in thymus, while myeloid cells (neutrophils, platelets) come from separate myeloid progenitors.
Hematopoiesis Lineage Tree
HSCs → Common myeloid progenitors (CMP: neutrophils, platelets via megakaryocytes) vs. CLPs (B cells, NK cells, T-cell precursors).
Explanation of All Options
| Option | Cells from Lymphoid Stem Cells? | Explanation |
|---|---|---|
| (A) Natural killer cells | Yes | NK cells develop directly from bone marrow CLPs. |
| (C) B lymphocyte | Yes | B cells mature fully in bone marrow from CLPs. |
| (B) Platelets | No | Megakaryocyte lineage from myeloid progenitors (CMP → MEP). |
| (D) Neutrophils | No | Granulocyte-monocyte progenitors (GMP) from myeloid lineage. |
| Choice | Combination | Correct? |
|---|---|---|
| 1. (A) and (D) | NK + Neutrophils | No: Neutrophils are myeloid. |
| 2. (A) and (C) | NK + B cells | Yes: Both lymphoid lineage. |
| 3. (A) and (B) | NK + Platelets | No: Platelets are myeloid. |
| 4. (C) and (D) | B cells + Neutrophils | No: Neutrophils are myeloid. |
