Q.73 Match List I with List II
| LIST I | LIST II |
|---|---|
| A. DNA polymerase β B. DNA polymerase δ C. DNA polymerase α D. DNA polymerase γ |
I. Primase II. DNA repair III. Mitochondrial DNA replication IV. Leading and lagging strands of DNA |
Choose the correct answer from the options given below:
- (A)–(I); (B)–(II); (C)–(III); (D)–(IV)
- (A)–(II); (B)–(IV); (C)–(I); (D)–(III)
- (A)–(III); (B)–(IV); (C)–(I); (D)–(II)
- (A)–(IV); (B)–(II); (C)–(I); (D)–(III)
Answer: (B) (A)–(II); (B)–(IV); (C)–(I); (D)–(III)
DNA polymerase β handles repair, δ synthesizes both leading/lagging strands, α contains primase activity, and γ replicates mitochondrial DNA, matching the standard eukaryotic assignments.
Option Analysis
Choice (A): (A)–(I); (B)–(II); (C)–(III); (D)–(IV)
Incorrect. α is primase (not C-III), β is repair (not A-I), γ is mitochondrial (not D-IV). Mismatches all except β-II.Choice (B): (A)–(II); (B)–(IV); (C)–(I); (D)–(III)
Correct. β (A) = DNA repair (II); δ (B) = leading/lagging strands (IV); α (C) = primase (I); γ (D) = mitochondrial replication (III).Choice (C): (A)–(III); (B)–(IV); (C)–(I); (D)–(II)
Incorrect. β does repair (not mitochondrial III), γ does mitochondrial (not D-II). Swaps β and γ roles.Choice (D): (A)–(IV); (B)–(II); (C)–(I); (D)–(III)
Incorrect. β does repair (not strands IV), δ does strands (not B-II). Swaps β and δ functions.DNA polymerase functions matching is a core molecular biology topic for exams like GATE Life Sciences, distinguishing eukaryotic polymerases: DNA polymerase β (repair), δ (leading and lagging strands), α (primase), and γ (mitochondrial DNA replication). This precise assignment reflects their specialized roles in replication and maintenance.
Key Function Assignments
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α (primase): Initiates with RNA primers for Okazaki fragments.
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β (repair): Short-patch base excision repair in nucleus.
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δ: Processive synthesis of lagging strand (with PCNA); some leading.
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γ: Sole mitochondrial replicase.
Polymerase Primary Role Key Feature α (C) Primase (I) RNA-DNA primer synthesis β (A) DNA repair (II) Nuclear BER pathway δ (B) Leading/lagging (IV) High processivity with PCNA γ (D) Mitochondrial (III) mtDNA replication Master DNA polymerase alpha beta delta gamma matching via central dogma pathways: nuclear replication (α/δ), repair (β), mitochondrial (γ). Essential for competitive biotech prep.
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