33. Tumor cells were isolated from a breast cancer patient. These cells were injected into nude mice and they were divided into four groups. Group 1 received EGF receptor-conjugated with […]
Category: CSIR NET Life Science Previous Year Questions and Solution cell biology
CSIR NET Life Science Previous Year Questions and Solution cell biology
Cancer
Chemotherapy Resistance in Cancer Stem Cells and the Role of Cell Cycle Heterogeneity
While testing the effect of several potent anti-cancer compounds on cycling human oral cancer cells, a student observed that a major percentage of cells showed dose-deep cell death after 12 […]
Cancer
Mechanisms of Breast Cancer Relapse: Chemo-resistant and Quiescent Cells Role
After successive surgery and chemotherapy, the tumor of a breast cancer patient subsided. However after almost 5 years, the tumor relapsed in a more aggressive manner and did not respond […]
Cancer
Breast Cancer Metastasis to the Lung: Mechanisms and Clinical Implications
A patient with breast cancer was given a dose of radiation along with chemotherapy and was apparently cured of the tumor. After five years, a tumor was noticed in the […]
Cancer
MDM2 Oncogene and p19ARF Tumor Suppressor: Key Regulators of p53 in Cancer
29. Cellular level of tumour suppressor protein p53 is maintained by the ubiquitin ligase protein, Mdm2. Over expression of Mdm2 was found to convert a normal cell into cancer cells […]
Cancer
Role of p53-MDM2 Interaction and c-Src Phosphorylation in Cancer Progression
The following statements have been proposed for a cancer cell. A. Binding of p53 with MDM2, a ubiquitin E3 ligase; is a precondition for cancer progression. B. Phosphorylation of a […]
Cancer
Mechanisms Behind Protein Upregulation in Cancer: Roles of mRNA Mutations and Protein Stability
In an experiment it was observed that a protein was upregulated in cancer tissues (compared to control tissues) that showed correlation with disease progression. Following are a few possibilities, which […]
Cancer
Interpreting Western Blot Results: Effects of Anti-Cancer Drugs on Cell Cycle, Signaling, and Apoptosis
26. A student treated cancer cells with an anticancer drug and perform western blot analysis. Which one of the following blots is the best representation under the control (C) and […]
Cancer
Interpreting Western Blot Analysis for Anti-Cancer Drug Effects on Cell Cycle and Apoptosis
25. A western blot analysis after treating cancer cells with a prospective anti-cancer drug is shown below: The following assumptions were made: A. The drug may have arrested the growth […]
Cancer
Identifying Oncogenes and Tumor Suppressor Genes Using Transgenic and Knockout Mice Models
Oncogenes and tumor suppressor genes are termed as cancer-critical genes. Increasingly powerful tools are now available for systematically searching the DNA or mRNAs of cancer cells for either significant mutations […]
