20. Phosphorylation of the a-subunit of elF2 at Ser 51 position in Saccharomyces cerevisiae leads to sequestration of elF2B, guanosine exchange factor. This phenomenon is (1) known to activate translation […]
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CSIR NET Life Science Previous Year Questions and Solution on EUKARYOTIC GENE REGULATION
HMG14: The Pioneer Factor in Chromatin Loop Activation and Gene Regulation
19. Prior to transcription, chromatin changes from an inactive state to an active state by various factors in a stepwise manner. Which one of the following is involved in the […]
CSIR NET Life Science Previous Year Questions and Solution on EUKARYOTIC GENE REGULATION
Histone Ubiquitination at Lysine Residues: A Key Post-Translational Modification in DNA Repair
18. The post-translational modifications in one or more core histones that are known to be associated with DNA repair pathways are: (1) Phosphorylation at specific tyrosine residues (2) Ubiquitination at […]
![17. The 5' UTR of ferritin mRNA forms a stem-loop structure called the iron regulatory element (IRE). The Iron Regulatory Binding Protein [IRBP] binds this IRE. The following statements were made with reference to IRBP- IRE interaction: (A) IRBP-IRE interaction prevents elF4A from resolving the stem-loop structure, thus preventing initiation of translation of ferritin genes. (B) IRBP-IRE interaction recruits elF4A to the 5' UTR, thus promoting translation initiation. (C) In presence of ferrous ions IRBP is unable to bind the IRE. (D) elF4A binds directly at the 5' UTR and disrupts the stem-loop structure, thus promoting translation initiation. Which one of the options below represents the combination of all correct statements? (1) B only (2) A and D (3) A and C (4) B and C](https://www.letstalkacademy.com/wp-content/uploads/2025/06/17-2.jpg)
CSIR NET Life Science Previous Year Questions and Solution on EUKARYOTIC GENE REGULATION
Iron Regulation of Ferritin Translation: The Role of IRP, IRE, and eIF4A
17. The 5′ UTR of ferritin mRNA forms a stem-loop structure called the iron regulatory element (IRE). The Iron Regulatory Binding Protein [IRBP] binds this IRE. The following statements were […]
CSIR NET Life Science Previous Year Questions and Solution on EUKARYOTIC GENE REGULATION
Autogenous Translational Regulation of Ribosomal Protein Genes in E. coli: Maintaining Stoichiometric Balance
16. Regulation of mRNA translation is a major mechanism that maintains stoichiometric availability of ribosomal proteins (r-proteins) to rRNA molecules they bind to. Translational regulation is facilitated by general occurrence […]
CSIR NET Life Science Previous Year Questions and Solution on EUKARYOTIC GENE REGULATION
How eIF2α Phosphorylation Regulates Translation by Sequestering eIF2B
15. Phosphorylation of elF2 α subunits (at Ser 51) leads to (1) inactivation of Met-tRNAi, binding activity of elF2B. (2) sequestration of eIF2B because of tight binding between elF2 and […]
CSIR NET Life Science Previous Year Questions and Solution on EUKARYOTIC GENE REGULATION
eIF2α Phosphorylation: The Central Mechanism for Translational Control During Cellular Stress
14. During eukaryotic protein synthesis, stress conditions result in activation of specific kinases leading to phosphorylation of a key translation initiation factor that inhibits protein synthesis from a large number […]
CSIR NET Life Science Previous Year Questions and Solution on EUKARYOTIC GENE REGULATION
eIF4E Overexpression Drives Neoplastic Transformation: Implications for Cancer Progression
13. The cap binding protein (elF4E), which is involved in the global regulation of translation, is highly regulated in eukaryotic cells. In an experiment, a researcher transfected mammalian cells with […]
CSIR NET Life Science Previous Year Questions and Solution on EUKARYOTIC GENE REGULATION
How Mammalian Cells Regulate Protein Synthesis During Heat Shock: The Role of IRES and Hsp mRNA Abundance
12. During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins (Hsps). The possible molecular regulation(s) that could explain the phenomenon are: A. mRNA of […]
CSIR NET Life Science Previous Year Questions and Solution on EUKARYOTIC GENE REGULATION
How TOR Regulates rRNA Synthesis via Transcription Factor-Pol I Interaction: Insights from Rapamycin Studies and Fusion Protein Experiments
11. one of the cellular events that TOR. a kinase, positively regulates is the rate of rRNA synthesis. TOR regulates the association of a transcription factor to a POI I […]
