119. Match List I with List II
LIST I                                                                                                     LIST II
A. Interleukin-2 (IL-2)                                                                     I. Activates NK cells and T cells; potently induces production of Interferons; shifts immune response to 𝑇𝐻1
B. Interferon-𝛾 (IFN-𝛾)                                                                   II. Major mediator of inflammation; stimulate macrophages and cytokine production
C. Tumor necrosis factor (TNF)                                                 III. Strong macrophage-activating factor; causes a variety of cells to express class II MHC molecules.
D. Interleukin-12 (IL- 12)                                                              IV Major growth factor for T and B cells; enhances cytolytic activity of natural killer cells
Choose the correct answer from the options given below:
1. A-I, B-II, C-III, D-IV
2. A-IV, B-II, C-III, D-I
3. A-III. B-IV, C-I, D-II
4. A-IV, B-III, C-II, D-I

Correct Answer:

4. A-IV, B-III, C-II, D-I

Explanation:

Let’s match each cytokine in List I with its correct function from List II:

A. Interleukin-2 (IL-2) → IV

• Function: IL-2 is a major growth factor for T cells and B cells. It also enhances the cytolytic activity of NK (natural killer) cells.

• Match: IV

B. Interferon-γ (IFN-γ) → III

• Function: IFN-γ is a strong macrophage-activating factor. It also induces expression of MHC class II molecules on various cell types.

• Match: III

C. Tumor Necrosis Factor (TNF) → II

• Function: TNF is a major mediator of inflammation. It stimulates macrophages and promotes cytokine production, playing a key role in the inflammatory response.

• Match: II

D. Interleukin-12 (IL-12) → I

• Function: IL-12 activates NK cells and T cells, potently induces interferon production, and shifts the immune response toward a TH1 phenotype (cell-mediated immunity).

• Match: I

Final Matching:

• A – IV

• B – III

• C – II

• D – I

Conclusion:

Each cytokine plays a critical and distinct role in immune signaling. The correct match confirms that: Interleukin-2 supports growth and cytolytic activity,
IFN-γ activates macrophages,
TNF promotes inflammation, and
IL-12 activates NK cells and induces interferons.

Thus, the correct answer is:
4. A-IV, B-III, C-II, D-I.