Q.43 Malignant tumor cells have the following properties:

1. Unregulated cell division
2. Inhibition of angiogenesis
3. Resistance to apoptosis
4. Cellular immortality
5. Ability to metastasis

Choose the correct answer from the options given below:

1. A, B, C and D only
2. A, B, D and E only
3. A, C, D and E only
4. B, C, D and E only

   Malignant tumors drive cancer through hallmark traits like endless division and spread. This MCQ tests core cancer biology concepts from Hanahan and Weinberg’s principles.

   Properties Breakdown

   A. Unregulated cell division
   True. Cancer cells ignore growth signals, evading cell cycle checkpoints for continuous proliferation.

   B. Inhibition of angiogenesis
   False. Tumor cells promote angiogenesis via VEGF secretion, forming new blood vessels for nutrients and oxygen supply.

   C. Resistance to apoptosis
   True. Mutations in p53 or Bcl-2 overexpression prevent programmed cell death, allowing survival.

   D. Cellular immortality
   True. Telomerase activation maintains telomeres, enabling unlimited divisions unlike normal cells.

   E. Ability to metastasis
   True. Cancer cells invade tissues, enter circulation, and colonize distant sites.

   Correct Answer: Option 3 (A, C, D and E only)

   Excludes B, matching cancer hallmarks—angiogenesis is stimulated, not inhibited.

   All Options Explained

   Option	Properties Included	Correct?	Why?
   1. A, B, C, D	Adds B	No	B wrong—tumors induce angiogenesis for growth
   2. A, B, D, E	Adds B	No	B incorrect; skips true C (apoptosis resistance)
   3. A, C, D, E	Core hallmarks	Yes	All true: unregulated growth, anti-death, immortal, metastatic
   4. B, C, D, E	Adds B, skips A	No	B false; misses division hallmark

   These traits distinguish malignant from benign tumors—vital for oncology exams and research.