The correct figure representing the conditions under which mice succumbed to lymphomas in the experiment designed to establish the synergy of Bcl2 with genes like Myc is:

Option 3

Explanation

• Studies show a marked synergy between Bcl2 and Myc in transgenic mice, leading to aggressive B-cell lymphomas. Mice co-expressing both genes develop tumors much faster and have significantly shorter lifespans compared to mice expressing either gene alone.​

• The lymphoma-bearing mice exhibit enlarged lymphoid organs and infiltration of B-cells into non-lymphoid tissues such as lung, liver, and kidney, indicative of aggressive lymphoma.

• Survival curves indicate that mice with both Bcl2 and Myc expression succumb earlier, showing that the combination accelerates tumor onset and lethality.​

• Expression of either gene alone leads to less aggressive disease and longer survival.