Q.81 Match the infectious agents in Group I with the associated diseases in Group II
| Group I | Group II |
|---|---|
| P. Bordetella pertussis Q. Mycobacterium leprae R. Haemophilus influenzae S. Rubella |
I. Mumps II. Meningitis III. Tuberculosis IV. Whooping cough V. Hansen’s disease |
Bordetella pertussis causes whooping cough (P-IV), Mycobacterium leprae causes Hansen’s disease (Q-V), Haemophilus influenzae causes meningitis (R-II), and Rubella causes congenital rubella syndrome (not mumps; S doesn’t match perfectly but closest elimination leads to option A). The correct answer is (A). [web:previous knowledge]
Correct Answer
(A) P-IV, Q-V, R-II, S-I
Disease-Agent Matches
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P. Bordetella pertussis → IV. Whooping cough: Gram-negative coccobacillus causing pertussis with paroxysmal coughing and whooping sound via pertussis toxin.
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Q. Mycobacterium leprae → V. Hansen’s disease: Acid-fast bacillus causing leprosy (tuberculoid/lepromatous forms); grows only in cooler body areas (skin, nerves). [standard microbiology]
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R. Haemophilus influenzae → II. Meningitis: Type b (Hib) causes bacterial meningitis in unvaccinated children; encapsulated, requires chocolate agar. [standard microbiology]
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S. Rubella → I. Mumps: Note: Rubella causes German measles/congenital rubella syndrome; mumps is paramyxovirus (parotitis). Option A is closest by elimination as other matches perfect.
Option Analysis
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(A) P-IV, Q-V, R-II, S-I: Correct for P/Q/R; S imperfect but best fit (no congenital meningitis listed).
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(B) P-V, Q-III, R-I, S-IV: Wrong. Pertussis ≠ Hansen’s; leprae ≠ TB (M. tuberculosis); H. flu ≠ mumps.
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(C) P-I, Q-III, R-V, S-IV: Wrong. Pertussis ≠ mumps; leprae ≠ TB; H. flu ≠ Hansen’s.
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(D) P-III, Q-II, R-V, S-I: Wrong. Pertussis ≠ TB; leprae ≠ meningitis.
Introduction to Infectious Agents Disease Matching
Bordetella pertussis whooping cough Mycobacterium leprae Hansen’s disease matching in GATE Life Sciences Q.81 tests core microbiology: pertussis (P-IV), leprosy (Q-V), Hib meningitis (R-II). Option (A) correctly pairs agents with hallmark diseases despite minor rubella ambiguity.
Perfect Disease Matches
| Agent | Disease | Key Features |
|---|---|---|
| P. Bordetella pertussis | IV. Whooping cough | Paroxysmal cough, PT toxin |
| Q. Mycobacterium leprae | V. Hansen’s disease | Armadillo-grown, neural damage |
| R. Haemophilus influenzae | II. Meningitis | Hib vaccine-preventable |
| S. Rubella | I. Mumps | Elimination choice (German measles) |
Q.81 Why Option A Wins
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P-IV: Classic pertussis agent (DTP vaccine).
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Q-V: “Hansen” = leprosy eponym.
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R-II: #1 pediatric bacterial meningitis pre-vaccine.
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S-I: Only remaining pair; rubella ≠ others listed.
Answer: (A)—3/4 perfect, standard GATE pattern.
Clinical Hallmarks for Exams
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Whooping cough: Lymphocytosis, culture on Bordet-Gengou.
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Hansen’s: Ridley cells, dapsone-rifampin.
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Hib meningitis: Chocolate agar, Quellung reaction.
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Rubella: TOSCRIES (congenital defects).
GATE Microbiology Tips
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Mnemonic: “Pertussis Whoops (P-IV), Leprosy Hansen’s (Q-V), Hib Meningitis (R-II).”
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High-yield: Vaccine-preventable (DTP, Hib, MMR).
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Trap: TB = M. tuberculosis (not leprae).
Master Bordetella pertussis whooping cough Mycobacterium leprae Hansen’s disease matching for perfect infectious disease scores.
