The correct answer is:

(2) RhoA and PLC

Explanation:

In the non-canonical Wnt pathway, signaling occurs independently of β-catenin and involves activation of small GTPases such as RhoA and enzymes like phospholipase C (PLC). These effectors mediate changes in cytoskeletal dynamics, cell polarity, and calcium signaling, which are key features of the planar cell polarity (PCP) and Wnt/Ca2+ pathways. Dishevelled (Dvl) is involved upstream in both canonical and noncanonical pathways, but GSK-3 and APC are more associated with the canonical β-catenin pathway. Hence, RhoA and PLC are the key activators in non-canonical Wnt signaling.​

Summary

• The non-canonical Wnt pathway operates independently of β-catenin.

• It activates small GTPase RhoA and phospholipase C (PLC) downstream of Frizzled and Dishevelled.

• RhoA influences cytoskeletal rearrangements; PLC triggers intracellular calcium release.

• These processes regulate cell movement, polarity, and morphogenesis during development.

Answer: (2) RhoA and PLC are most likely activated in the non-canonical Wnt pathway.​