Q.69 Match List I with List II
| List I (Condition) | List II (Characteristics) | ||
|---|---|---|---|
| Label | Condition | Label | Characteristics |
| A | Color blindness | I | Deficiency of clotting factor VIII |
| B | Hemophilia B | II | Insensitivity to green and red light |
| C | Hemophilia A | III | Deficiency of clotting factor IX |
| D | G-6-PD deficiency | IV | Severe anemic condition |
Choose the correct answer from the options given below:
- (A) – (I), (B) – (II), (C) – (III), (D) – (IV)
- (A) – (II), (B) – (I), (C) – (III), (D) – (IV)
- (A) – (IV), (B) – (I), (C) – (II), (D) – (III)
- (A) – (II), (B) – (III), (C) – (I), (D) – (IV)
Hemophilia A matches clotting factor VIII deficiency, Hemophilia B with factor IX, color blindness involves red-green insensitivity, and G-6-PD deficiency causes hemolytic anemia. The correct matching is option 4: (A)-(II), (B)-(III), (C)-(I), (D)-(IV).
Genetic Disorders Overview
These X-linked conditions show sex-biased inheritance: males express recessive traits from carrier mothers.
Color blindness and hemophilias stem from X mutations; G-6-PD from X-linked enzyme defect causing oxidative hemolysis.
Characteristics distinguish bleeding (hemophilia) from vision (color blindness) and anemia (G-6-PD).Correct Answer: (A)-(II), (B)-(III), (C)-(I), (D)-(IV)
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A. Color blindness → II. Insensitivity to green and red light: X-linked OPN1LW/OPN1MW mutations impair L/M-cones.
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B. Hemophilia B → III. Deficiency of clotting factor IX: F9 gene mutation; milder than A.
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C. Hemophilia A → I. Deficiency of clotting factor VIII: F8 gene; most common severe bleeding disorder.
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D. G-6-PD deficiency → IV. Severe anemic condition: G6PD gene; hemolytic crises triggered by drugs/infections.
Option Breakdown
Option Matching Explanation Correct? 1 A-I, B-II, C-III, D-IV Swaps hemophilias backward; color blindness ≠ factor VIII. No 2 A-II, B-I, C-III, D-IV Hemophilia B wrong (IX not VIII); rest ok. No 3 A-IV, B-I, C-II, D-III Mismatches all: color blindness ≠ anemia, hemophilias/color vision swapped. No 4 A-II, B-III, C-I, D-IV Perfect: red-green (A-II), F9 (B-III), F8 (C-I), hemolytic anemia (D-IV). Yes Inheritance Patterns
All X-linked recessive: 1/3 males affected for color blindness (~8%), hemophilia A (~1/5000); G-6-PD highest (~400M carriers).
Females need two mutated Xs; carriers show skewed inactivation effects. -
