Q.8 Match List-I with List-II
| List-I | List-II |
|---|---|
| (Coenzyme) | (Precursor) |
| (A) Coenzyme A | (I) Vitamin B1 |
| (B) FAD, FMN | (II) Pantothenic Acid |
| (C) NAD+, NADP+ | (III) Vitamin B2 |
| (D) Thiamine pyrophosphate | (IV) Niacin |
Choose the correct answer from the options given below:
- (A) – (I), (B) – (II), (C) – (III), (D) – (IV)
- (A) – (I), (B) – (III), (C) – (II), (D) – (IV)
- (A) – (II), (B) – (III), (C) – (IV), (D) – (I)
- (A) – (III), (B) – (IV), (C) – (I), (D) – (II)
Coenzyme A derives from pantothenic acid (vitamin B5, option II), FAD/FMN from riboflavin (vitamin B2, III), NAD+/NADP+ from niacin (IV), and thiamine pyrophosphate from thiamine (vitamin B1, I). The correct match is option (C): (A)-(II), (B)-(III), (C)-(IV), (D)-(I).
Question Breakdown
This matching tests coenzyme-vitamin precursor relationships key to biochemistry metabolism. Each coenzyme relies on a specific vitamin for synthesis.
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(A) Coenzyme A: Precursor pantothenic acid (II), vital for acyl transfers in TCA cycle and fatty acid metabolism.
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(B) FAD, FMN: Precursor riboflavin/vitamin B2 (III), used in redox reactions like electron transport.
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(C) NAD+, NADP+: Precursor niacin/vitamin B3 (IV), central to oxidation-reduction in glycolysis and respiration.
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(D) Thiamine pyrophosphate: Precursor thiamine/vitamin B1 (I), cofactor for decarboxylases in pyruvate metabolism.
Option Analysis
Option A→ B→ C→ D→ Correct? Reason First (I) (II) (III) (IV) No Wrong: CoA not from B1 (thiamine); FAD not B5 . Second (I) (III) (II) (IV) No Wrong: CoA not B1; NAD+ not B5 . Third (II) (III) (IV) (I) Yes All precursors match standard biochemistry . Fourth (III) (IV) (I) (II) No Wrong: CoA not B2; mismatches all . Coenzyme precursor matching is essential for GATE Life Sciences students mastering vitamin-derived cofactors in metabolism. This article solves a key PYQ on Coenzyme A, FAD/FMN, NAD+/NADP+, and thiamine pyrophosphate precursors.
Coenzyme-Vitamin Links
Vitamins form coenzymes critical for enzymatic reactions. Pantothenic acid (B5) builds Coenzyme A for acetyl-CoA; riboflavin (B2) yields FAD/FMN for flavoproteins; niacin (B3) produces NAD+/NADP+ for dehydrogenases; thiamine (B1) activates TPP for aldolases.
Solved Matching Question
Match List-I coenzymes to List-II precursors:
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(A) Coenzyme A → (II) Pantothenic Acid
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(B) FAD, FMN → (III) Vitamin B2
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(C) NAD+, NADP+ → (IV) Niacin
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(D) Thiamine pyrophosphate → (I) Vitamin B1
Correct Option: (A)-(II), (B)-(III), (C)-(IV), (D)-(I).
Exam Tips
Recall: Deficiencies disrupt specific pathways—e.g., B1 lack impairs pyruvate dehydrogenase. Use mnemonics like “CoA from Pan” for pantothenic acid. Practice for GATE biochemistry section.
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