Q.48 Match List I with List II
| LIST I Cell Types |
LIST II Niches |
||
|---|---|---|---|
| A. | Brain (Neurons & Glia) | I. | Ventricular & Sub-ventricular zone |
| B. | Mesenchymal stem cells | II. | Bone marrow |
| C. | Kupffer cells | III. | Liver |
| D. | Hematopoietic stem cells | IV. | Adipose tissue, placenta, bone marrow |
Choose the correct answer from the options given below:
- A-I, B-II, C-III, D-IV
- A-III, B-II, C-I, D-IV
- A-I, B-IV, C-III, D-II
- A-IV, B-III, C-II, D-I
Neural stem cells in brain reside in ventricular & sub-ventricular zones, hematopoietic stem cells in bone marrow, mesenchymal stem cells in adipose/bone marrow/placenta, Kupffer cells in liver.
The correct matching is A-I, B-IV, C-III, D-II.
Question Breakdown
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A. Brain (Neurons & Glia): Neural progenitors (type B cells) in ventricular & sub-ventricular zone (V-SVZ) neurogenic niche
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B. Mesenchymal stem cells: Found in adipose tissue, placenta, bone marrow (multipotent stromal cells)
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C. Kupffer cells: Liver-resident macrophages; niche in sinusoids with stellate/hepatocyte/endothelial interactions
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D. Hematopoietic stem cells: Bone marrow endosteal/perivascular niche
Option Analysis
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A-I, B-II, C-III, D-IV: Wrong (MSCs ≠ bone marrow exclusive)
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A-III, B-II, C-I, D-IV: Wrong (brain ≠ liver)
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A-I, B-IV, C-III, D-II: Correct (precise niche locations)
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A-IV, B-III, C-II, D-I: Wrong (brain ≠ adipose)
Correct Answer
A-I, B-IV, C-III, D-II
Stem Cell Niches Overview
Stem cell niches maintain self-renewal/differentiation. Brain (Neurons & Glia) neural stem cells reside in ventricular & sub-ventricular zone (V-SVZ), generating olfactory interneurons. Mesenchymal stem cells occupy adipose tissue, placenta, bone marrow for osteo/chondro/adipo lineages. Kupffer cells (liver macrophages) niche in hepatic sinusoids. Hematopoietic stem cells in bone marrow osteoblastic/vascular niches.
Correct Matching Table
Cell Type Niche A. Brain (Neurons & Glia) I. Ventricular & Sub-ventricular zone (neurogenesis) B. Mesenchymal stem cells IV. Adipose tissue, placenta, bone marrow C. Kupffer cells III. Liver (sinusoidal resident) D. Hematopoietic stem cells II. Bone marrow (HSC niche) Niche Functions
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V-SVZ: Fractones/BM support B1 cells → neuroblasts
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MSC sites: Immunomodulation, tissue repair
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Kupffer: Monocyte imprinting via stellate/endothelial
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BM HSC: CXCL12+ CAR cells maintain quiescence
Exam Strategy
NEET/GATE mnemonic: “Brain-Vent, Heme-BM, MSC-multi, Kupffer-Liver”. Option 3 perfect. Distractor: confusing HSCs/MSCs both BM but different niches.
Key stem cell biology question for your advanced life sciences prep.
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