Q.39 Match the autoimmune diseases in Group I with the corresponding
primarily affected organ in Group II.
Group I Group II
P. Hashimoto’s disease 1. Brain
Q. Juvenile diabetes 2. Pancreas
R. Multiple sclerosis 3. Skeletal muscle
S. Myasthenia gravis 4. Thyroid
(A) P-1, Q-2, R-3, S-4
(B) P-3, Q-1, R-2, S-4
(C) P-4, Q-2, R-1, S-3
(D) P-1, Q-2, R-4, S-3
Hashimoto’s Disease to Myasthenia Gravis: Correct Matching of Autoimmune Diseases with Affected Organs
Hashimoto’s disease targets the thyroid gland, while Juvenile diabetes affects the pancreas in this classic matching question. The correct pairing follows standard medical pathology for these conditions.
Correct Answer
Option (C) P-4, Q-2, R-1, S-3 is correct.
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P. Hashimoto’s disease → 4. Thyroid: Immune attack destroys thyroid cells, causing hypothyroidism.
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Q. Juvenile diabetes → 2. Pancreas: Type 1 diabetes involves autoantibodies against beta cells, halting insulin production.
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R. Multiple sclerosis → 1. Brain: Demyelination primarily strikes the central nervous system, including brain white matter.
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S. Myasthenia gravis → 3. Skeletal muscle: Antibodies block neuromuscular junctions, weakening voluntary muscles.
All Options Explained
Option (A) P-1, Q-2, R-3, S-4 fails because Hashimoto’s links to thyroid (4), not brain (1), and multiple sclerosis targets brain (1), not skeletal muscle (3).
Option (B) P-3, Q-1, R-2, S-4 mismatches Hashimoto’s (thyroid 4, not skeletal muscle 3) and swaps Juvenile diabetes (pancreas 2) with MS (brain 1).
Option (C) P-4, Q-2, R-1, S-3 aligns perfectly with primary organ involvement in each autoimmune pathology.
Option (D) P-1, Q-2, R-4, S-3 incorrectly assigns Hashimoto’s to brain (1) instead of thyroid (4) and MS to thyroid (4) instead of brain (1).
Why This Matters for GATE BT
This question tests core immunology knowledge relevant for biotech exams, emphasizing antibody-mediated organ-specific autoimmunity. Review thyroiditis and neuromuscular disorders for similar MCQs.
