Q.36 Match items in Group I with Group II.
| Group I | Group II |
|---|---|
| P. Alzheimer’s disease Q. Mad cow disease R. Sickle cell anaemia S. Swine flu |
1. H1N1 2. Hemoglobin 3. Prions 4. Amyloid |
(A) P-4, Q-3, R-2, S-1
(B) P-3, Q-4, R-1, S-2
(C) P-2, Q-1, R-4, S-3
(D) P-1, Q-2, R-3, S-4
Correct Answer: (A) P-4, Q-3, R-2, S-1
Alzheimer’s disease involves amyloid plaques, Mad cow disease stems from prions, sickle cell anaemia arises from hemoglobin mutation, and swine flu is caused by H1N1 virus. Option (A) accurately matches these associations.
Option Analysis
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(A) P-4, Q-3, R-2, S-1: Correct. Alzheimer’s links to amyloid proteins forming plaques; Mad cow (BSE) to prions; sickle cell anaemia to defective hemoglobin; swine flu to H1N1 influenza.
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(B) P-3, Q-4, R-1, S-2: Incorrect. Prions (3) do not cause Alzheimer’s (P); amyloid (4) unrelated to Mad cow (Q); H1N1 (1) not for sickle cell (R).
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(C) P-2, Q-1, R-4, S-3: Incorrect. Hemoglobin (2) causes sickle cell (R), not Alzheimer’s (P); H1N1 (1) for swine flu (S), not Mad cow (Q).
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(D) P-1, Q-2, R-3, S-4: Incorrect. H1N1 (1) links to swine flu (S), not Alzheimer’s (P); hemoglobin (2) for sickle cell (R), not Mad cow (Q).
Alzheimer’s disease amyloid plaques, Mad cow disease prions, sickle cell anaemia hemoglobin defects, and swine flu H1N1 virus represent key disease-agent matches tested in Group I Group II questions like Q.36. These associations are essential for microbiology, molecular biology exams targeting biochemical engineering students.
Disease Mechanisms
Alzheimer’s features amyloid-beta aggregates disrupting neurons. Mad cow (BSE) involves prions causing spongiform encephalopathy. Sickle cell anaemia results from hemoglobin S polymerization under low oxygen. Swine flu pandemic arose from H1N1 influenza A strain.
Matching Accuracy
Correct pairing: P-Alzheimer’s to 4-amyloid, Q-Mad cow to 3-prions, R-sickle cell to 2-hemoglobin, S-swine flu to 1-H1N1 (option A). Errors in other options misalign protein/viral causes with diseases.
Exam Preparation Tips
Focus on pathogen-protein links for biotechnology GATE questions. Relate to enzyme kinetics in disease models and genetic mutations in hemoglobinopathies, aligning with molecular biology expertise.
