Blog

40. Which of the following statement is NOT true about small interfering RNA (siRNA)? (1) siRNA has 21-25 nucleotide sequence with 2 nucleotide overhang at 3′ end (2) siRNA is […]

39. In an experiment, intact chromatin was isolated and digested with micrococcal nuclease in independent tubes for 30 min, 1 h, 2h, and 4h. Further, the DNA was purified from […]

38 human, protein coding genes are mainly organized “exons” and “introns’’. There are intergenic regions that transcribe into various types of non-coding RNA (nottranslating into protein). Some introns may harbor […]

37. Following statements are made about chromatin re-modelling in human cells: A. Local chromatin conformation may play more important role than the local DNA sequence of the promoter. B. Histones […]

36. The amino acid side chains of the four histones in the nucleosome are subjected to remarkable variety of post-translation modifications such as phosphorylation, acetylation and methylation. Which one of […]

35. Chromatin re-modelling leading to histone modifications is invariably required for regulation of transcriptional activity of eukaryotic genes. The residues in histone tails may be methylated or acetylated, The nature […]

34. Following statements were made about some of the characteristics of the human genome: (A) Evidence derived by chromosome conformation capture (3C) suggests that each chromosome comprised a series of […]

33. Following statements were made about chromatin remodeling in eukaryotes: (A) Chromatin remodeling completely alters and/or slides the nucleosome, but cannot displace it. (B) Chromatin remodeling is an energy driven, […]

32. Readers of histone modifications include: (1) SUN domain proteins (2) BAG domain proteins (3) PAS domain proteins (4) TUDOR domain proteins   Introduction Histone modifications are fundamental to the […]

31. The mammalian protein HP1 plays a major role in heterochromatinization and silencing. The following mutations are proposed to negatively impact HP1 function. A. Mutation inactivating the deacetylase that targets […]