63. A ligand recognizes two different cell surface receptors. A and B, on the same cell type. Receptor A. after with the ligand internalized along with the ligand whereas receptor […]
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CSIR NET Life Science Previous Year Questions and Solution cell biology
Glucocorticoid Receptor-Mediated Nuclear Translocation of β-Galactosidase Fusion Proteins: Experimental Insights
62. Cultured animal cells were transfected with expression vector encoding either ß-galactosidase (β-gal) alone or expressing a fusion protein of β-gal and glucocorticoid receptor (GR). After transfection. cells were kept […]
CSIR NET Life Science Previous Year Questions and Solution cell biology
Challenges in Designing Retinoic Acid Receptor-Targeting Drugs: Membrane Permeability and Binding Considerations
61. A pharmacy student designed a drug to specifically target the receptors for retinoic acid in order to prevent stem cell differentiation. After in vitro trial, the investigator found that […]
CSIR NET Life Science Previous Year Questions and Solution cell biology
Structural Regions and Functional Insights of Nuclear Receptors: Decoding Domains A-F
60. Based on the structural regions of a nuclear receptorshown in the diagram, the following predictions weremade. A) Region F is responsible for binding to ligands and contains two zinc […]
CSIR NET Life Science Previous Year Questions and Solution cell biology
Nuclear Receptor Superfamily: Clarifying Common Misconceptions and Structural Features
59. Which one of the following state about the nuclear receptor super family is NOT true? (1) The receptors are always cytosol where they remain associated with heat-shock proteins and […]
CSIR NET Life Science Previous Year Questions and Solution cell biology
Localization of Heat Shock Protein Binding Site in the Glucocorticoid Receptor Ligand-Binding Domain
58. Heat shock protein binding region is located in which one of the following domains of glucocorticoid receptor protein? (1) DNA-binding (2) Ligand-binding (3) N-terminal (4) Hinge region Heat Shock […]
CSIR NET Life Science Previous Year Questions and Solution cell biology
Hybrid Steroid Receptors: Ligand Binding and DNA Binding Domain Specificity Explained
57 Two steroid hormone receptors and Y both contain a ligand binding domain recombinant DNA technology, a modified hybrid receptor H is prepared such that it contains the ligand binding […]
CSIR NET Life Science Previous Year Questions and Solution CELL SIGNALING
Combination of Nuclear Localization Sequence and Zinc Finger Motif in Cytoplasmic Steroid Receptors
56, Which one of the following combinations be present in a steroid receptor that is located in the cytoplasm? (1) Nuclear export sequence (NES), leucine zipper (2) NES, zinc finger […]
CSIR NET Life Science Previous Year Questions and Solution cell biology
Where Are Steroid Hormone Receptors Located? Nuclear, Cytoplasmic, and Membrane Pools Explained
55. Receptors for signaling for steroid hormones are located at (1) Plasma membrane (2) organelle membrane (3) Intracellular (4) No receptor Introduction Steroid hormones regulate crucial physiological processes by […]
CSIR NET Life Science Previous Year Questions and Solution cell biology
Phorbol Ester Activation of NF-κB in Pre-B Cells: Clarifying the Signaling Mechanisms
54. Which of the following statement is INCORRECT inrelation to treatment of pre-B cell with phorbol ester? (i) Phorbol esters activates NF-kB for translocation into nucleus (2) Phorbol esters activate […]
