Out of the statements mentioned below A. L-threonine and L-allo-threonine interact identically with plane polarized light. B. van der Waals’ interactions are always attractive. C. Poly (pro) ll-helix is not […]
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The β-α-β Motif: Structure, Function, and Role in Ligand Binding
35. β-α-β motif is composed of two beta strands joined by an alpha helix through connecting loops. This motif is known for (1) ligand binding (2) stereological hindrance in binding […]
Hydrogen Bonding in Alpha-Helices, Beta-Turns, and Beta-Sheets
Following statements are made related to protein structure A. The hydrogen bonding patterns between the CO and NH groups are n → n +3 in α-helix; n → n + […]
Structural Analysis of Adenylate Kinase
Phosphorylation of ADP to ATP occurs through energy metabolism, comprising oxidative phosphorylation or substrate level phosphorylation or photo- phosphorylation (in plants). ATP can also be formed from ADP through the […]
Impact of Alanine-to-Glycine Substitution on Protein Structure
A protein has 30% alanine. If all the alanines are replaced by glycines, (1) helical content will increase. (2) ß-sheet content will increase. (3) there will be no change in […]
Alpha-Helix in Protein Structure: Hydrogen Bonding and Stability
Which is correct for α-helix of a protein (1) It has H-bonding in two or more parallel running chains (2) There is intra-chain H-bonding in single helix (3) No H- […]
Understanding Amino Acid Propensity in Protein Secondary Structure
The following statements describe the propensity and role of amino acids in the secondary structure of proteins A. Alanine has a high frequency of occurrence in α- helices B. Proline […]
Time Required for a Polypeptide Backbone to Explore All Possible Conformations
How long should it take the polypeptide backbone of a 6-residue, 10-residue, 15-residue and 20- residue folding nucleus to explore all its possible conformations? Assume that the polypeptide backbone randomly […]
Estimating Possible Conformations of a 51-Residue Protein
Consider a 51-residue long protein containing only 100 bonds about which rotation can occur. Assume that 3 orientations per bond are possible. Based on these assumptions, how many conformations will […]
Determining the Length of an α-Helical Section in a Membrane
26. The length of an α-helical section of a polypeptide chain of 20 residues spanning hydrophobic region of membrane would be (1) 30 A (2) 54 A (3) 5.4 A […]


