Q.22 Match the microorganisms in Group I with the human disease in Group II
Group I Group II
P) Treponema pallidum 1) Sleeping sickness
Q) Trypanosoma cruzi 2) Whooping cough
R) Trypanosoma gambiense 3) Chagas disease
S) Bordetella pertussis 4) Syphilis
(A) P–4, Q–3, R–1, S–2
(B) P–1, Q–2, R–4, S–3
(C) P–3, Q–1, R–2, S–4
(D) P–2, Q–1, R–3, S–4
Option (A) P-4, Q-3, R-1, S-2 is correct. Treponema pallidum causes syphilis, Trypanosoma cruzi causes Chagas disease, Trypanosoma gambiense causes sleeping sickness, and Bordetella pertussis causes whooping cough.
Microorganism-Disease Matches
Treponema pallidum (P) is a spirochete bacterium responsible for syphilis (4), a sexually transmitted infection affecting multiple organ systems.
Trypanosoma cruzi (Q), a protozoan parasite, causes Chagas disease (3), transmitted by triatomine bugs and leading to cardiac and gastrointestinal complications.
Trypanosoma gambiense (R), another trypanosome subspecies, causes sleeping sickness (1), or African trypanosomiasis, characterized by neurological decline after a hemolymphatic phase.
Bordetella pertussis (S), a gram-negative bacterium, causes whooping cough (2), or pertussis, marked by severe paroxysmal coughing.
Option Analysis
Option A (Correct): Matches all accurately: P-syphilis, Q-Chagas, R-sleeping sickness, S-whooping cough.
Option B (Incorrect): Wrongly assigns P to sleeping sickness (trypanosome disease, not bacterial) and mixes others.
Option C (Incorrect): Misplaces P to Chagas (protozoan), R to whooping cough (bacterial), and others.
Option D (Incorrect): Assigns P to whooping cough (gram-negative coccobacillus) and swaps trypanosome diseases.
Treponema pallidum syphilis, Trypanosoma cruzi Chagas disease, Trypanosoma gambiense sleeping sickness, and Bordetella pertussis whooping cough represent key microorganism-human disease matches crucial for CSIR NET Life Sciences exam preparation. This question tests precise pathogen-disease associations across bacteria and protozoa.
Pathogen Profiles
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Treponema pallidum (Syphilis): Spirochete causing sexually transmitted syphilis with stages from chancre to neurosyphilis; treatable by penicillin.
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Trypanosoma cruzi (Chagas Disease): American trypanosomiasis parasite vectored by kissing bugs, leading to chronic heart failure.
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Trypanosoma gambiense (Sleeping Sickness): Causes chronic African trypanosomiasis via tsetse flies, progressing to meningoencephalitis.
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Bordetella pertussis (Whooping Cough): Produces pertussis toxin, causing respiratory paroxysms; vaccine-preventable but resurgent.
Exam Relevance
These matches appear frequently in CSIR NET microbiology sections, linking bacterial spirochetes, trypanosome protozoa, and gram-negative pathogens to specific syndromes like syphilis, Chagas, sleeping sickness, and whooping cough. Understanding transmission (sexual, vector-borne, airborne) aids differentiation.
