Q47.CRISPR is
(1) Clustered Regularly Interspaced Short Palindromic Repeats
(2) Coordinated Regularly Interspaced Short Palindromic Repeats
(3) Clustered Restrictive Interspaced Short Palindromic Regions
(4) Coordinated Restrictive Interspaced Short Palindromic Repeats

CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats, a bacterial immune system adapted for genome editing. The correct answer for Q47 is (1).​

Option Breakdown

• (1) Clustered Regularly Interspaced Short Palindromic Repeats: Correct. This is the exact definition—DNA repeats (24-48 bp) separated by unique spacers from past phage infections, with associated Cas proteins for defense.

• (2) Coordinated Regularly Interspaced Short Palindromic Repeats: Incorrect. “Coordinated” is wrong; CRISPR loci are clustered, not coordinated.

• (3) Clustered Restrictive Interspaced Short Palindromic Regions: Incorrect. “Restrictive” misdescribes spacers (which are variable phage-derived sequences), and it’s “Repeats,” not “Regions.”

• (4) Coordinated Restrictive Interspaced Short Palindromic Repeats: Incorrect. Combines errors from (2) and (3).​

Why (1) Only?

Discovered in 1987, formalized in 2002; “Clustered Regularly Interspaced Short Palindromic Repeats” is universal across sources—no valid alternatives exist.

Decode CRISPR Clustered Regularly Interspaced Short Palindromic Repeats for CSIR NET Life Sciences, NEET PG, and GATE exams. Q47 tests the exact full form of CRISPR—a prokaryotic adaptive immune system using repeat-spacer arrays against phages, revolutionized into Cas9 gene editing. Eliminate distractors and master exam tricks.

CRISPR Defined

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) consists of 24-48 bp palindromic repeats separated by unique spacers (phage DNA remnants), preceded by a leader sequence.

• Functions with Cas proteins (e.g., Cas9) to cleave invading DNA.

• Key in bacteria/archaea; adapted for precise genome editing since 2012 (Jinek et al.).

Correct Answer: (1)

Universal acronym since 2002 papers; no variations accepted in scientific literature.

Exam Insights

• CSIR NET trick: Changes one word (e.g., “Coordinated” vs. “Clustered”; “Restrictive” vs. “Regularly”).

• Mnemonic: Clustered Repeats, Regularly Interspaced, Short Palindromic.

• Applications: Gene knockout, therapy (e.g., sickle cell), agriculture.