Q.36 Which of the following cell types can develop from myeloid lineage?
(A) Macrophages (B) T lymphocytes (C) B lymphocytes (D) Erythrocytes
Macrophages develop from the myeloid lineage, while T and B lymphocytes arise from the lymphoid lineage, and erythrocytes also originate from myeloid progenitors. The correct answer is (A) Macrophages, as confirmed by standard hematopoietic differentiation pathways relevant to CSIR NET Life Sciences preparation.
Option Analysis
Hematopoietic stem cells (HSCs) in bone marrow differentiate into myeloid and lymphoid lineages via common progenitors.
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(A) Macrophages: Derived from monocytes via common myeloid progenitors (CMPs), which produce granulocytes, monocytes/macrophages, and other innate immune cells.
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(B) T lymphocytes: Arise from common lymphoid progenitors (CLPs) or lymphoid-primed multipotent progenitors (LMPPs), maturing in the thymus.
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(C) B lymphocytes: Develop from CLPs in bone marrow, committing to the lymphoid pathway without myeloid potential.
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(D) Erythrocytes: Form from megakaryocyte-erythroid progenitors (MEPs), a myeloid sub-lineage responsible for red blood cells.
HSCs branch into myeloid lineage cell types (e.g., macrophages, erythrocytes) and lymphoid types early in hematopoiesis, a core concept for CSIR NET Life Sciences. This distinction tests understanding of cellular organization and immune cell origins in Unit 2 syllabus.
Myeloid Progenitors
CMPs yield granulocytes/monocytes (including macrophages), erythrocytes, megakaryocytes, and dendritic cells. Macrophages differentiate from monoblasts via monocytes, expressing markers like CD68.
Lymphoid Counterparts
CLPs produce T lymphocytes (thymus-matured), B lymphocytes (bone marrow-matured), and NK cells, excluding myeloid fates.
CSIR NET Relevance
Questions like “Which cell types develop from myeloid lineage?” emphasize CMP vs CLP paths; macrophages exemplify innate immunity from myeloid stem cells. Erythrocytes highlight oxygen transport role.
