Two classes of genes – proto-oncogene and tumor suppressor gene usually contribute to the development of cancer. Following are some of the statements regarding both the genes. A. Proto-oncogenes result […]
Tag: Cancer
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Cancer
Cancer Cells vs Cancer Stem Cells: Key Differences and Treatment Challenges
Following statements have been proposed for cancer cells and cancer stem cells: A. Cancer cells mostly have mutations whereas cancer stem cells do not. B. Cancer cells divide to form […]
Cancer
Cancer and Stem Cells: Understanding the Origins and Misconceptions
Cancer is often believed to arise from stem cells rather than fully differentiated cells. Following are certain views related to the above statement. Which one of the following is NOT […]
Cancer
Conversion of Proto-Oncogenes to Oncogenes: Key Mechanisms and Processes
Conversion of proto-oncogene to oncogene may involve the following processes: A. mutation in coding sequence B. gene amplification C. chromosome rearrangement D. mutation in non-coding sequence Which one is appropriate? […]
Cancer
Role of Metalloproteases and Serine Proteases in Adenoma to Metastatic Adenocarcinoma Transition
When adenoma is converted to metastatic adenocarcinoma, which of the following combination of proteins is almost certainly to be degraded? (1) Type IV collagen and laminin. (2) Fibronectin and β2 […]
Cancer
Mechanism of Action of Methotrexate: Competitive Inhibition of Dihydrofolate Reductase
The mode of action of the anticancer drug methotrexate is through its strong competitive inhibition on (1) dihydrofolate reductase (2) thymidine synthase. (3) thymidine kinase. (4) adenylate cyclase. Final Answer The […]
Cancer
Types of Mutations that Activate Oncogenes: Understanding Gain of Function Mutations
17. The mutation in an oncogene falls under which of the following classes? (1) Loss of function mutation (2) Frame shift mutation (3) Gain of function mutation (4) Dominant negative […]
Cancer
Key Differences Between Normal and Transformed Cells: Immortality and Contact Inhibition
The main difference between normal and transformed cells (1) immortality and contact inhibition (2) shorter generation time and cell mobility (3) apoptosis and tumour suppressor gene hyper- function. (4) inactivation […]
Cancer
What is a Tumor Suppressor Protein? Definition and Key Functions
A tumour suppressor protein (1) is one whose function brings about regression of a tumour (2) one where mutations are shown to cause or are associated with tumour. (3) is […]
Cancer
Which Oncogene-Protein Match is Incorrect? Clarifying erbA, erbB, ras, and fos Functions
Out of the following matches of oncogenes with the proteins that each specifies, which one is incorrect? (1) erbA – thyroid hormone receptor. (2) erbB – epidermal growth factor receptor. […]
