Q45.Match List I with List II
List-I (Compound)
A. Dolichol
B. Vitamin-K
C. Vitamin-E
D. Warfarin
List-II (Function)
I. Blood clotting factor
II. Antioxidant
III. Anticoagulant
IV. Sugar carrier
Choose the correct answer from the options given below:
(A) A-IV, B-I, C-II, D-III
(B) A-III, B-I, C-IV, D-II
(C) A-III, B-IV, C-II, D-I
(D) A-II, B-III, C-IV, D-I
The correct answer is option (A): A-IV, B-I, C-II, D-III. This matches each compound from List-I to its primary biochemical function in List-II, based on well-established roles in glycosylation, coagulation, and oxidative protection.
Compound-Function Matches
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A. Dolichol → IV. Sugar carrier: Dolichol phosphate acts as a lipid carrier for oligosaccharides during N-linked protein glycosylation in the ER, transferring GlcNAc, mannose, and glucose units.
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B. Vitamin-K → I. Blood clotting factor: Vitamin K is essential for γ-carboxylation of clotting factors II, VII, IX, X, and proteins C/S, enabling Ca²⁺ binding and phospholipid interaction.
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C. Vitamin-E → II. Antioxidant: α-Tocopherol scavenges lipid peroxyl radicals in cell membranes, preventing polyunsaturated fatty acid oxidation and maintaining membrane integrity.
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D. Warfarin → III. Anticoagulant: Warfarin inhibits vitamin K epoxide reductase (VKOR), blocking vitamin K recycling and depleting active vitamin K for clotting factor carboxylation.
Option Analysis
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(A) A-IV, B-I, C-II, D-III: Correct. Dolichol carries sugars (IV); vitamin K enables clotting (I); vitamin E protects membranes (II); warfarin blocks coagulation (III).
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(B) A-III, B-I, C-IV, D-II: Incorrect. Dolichol isn’t an anticoagulant (III); vitamin E doesn’t carry sugars (IV).
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(C) A-III, B-IV, C-II, D-I: Incorrect. Vitamin K isn’t a sugar carrier (IV); warfarin doesn’t synthesize clotting factors (I).
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(D) A-II, B-III, C-IV, D-I: Incorrect. Dolichol lacks antioxidant activity (II); vitamin K isn’t an anticoagulant (III).
Dolichol, Vitamin-K, Vitamin-E, and Warfarin dominate match List I with List II questions testing glycosylation and coagulation pathways in NEET biology. This guide links sugar carrier (dolichol), blood clotting factor (vitamin K), antioxidant (vitamin E), and anticoagulant (warfarin) for perfect scoring.
Critical Biochemical Roles
Dolichol serves as the sugar carrier in N-glycosylation, anchoring Glc3Man9GlcNAc2 for protein folding quality control. Vitamin-K enables blood clotting factor carboxylation via γ-glutamyl carboxylase, activating factors II/VII/IX/X. Vitamin-E functions as a lipid-soluble antioxidant, terminating chain reactions in PUFA oxidation. Warfarin acts as a vitamin K antagonist anticoagulant by inhibiting VKORC1, prolonging prothrombin time.
Why Option (A) Perfectly Matches
Option (A) A-IV, B-I, C-II, D-III captures match List I with List II dolichol vitamin K warfarin precisely—dolichol defects cause congenital glycosylation disorders; warfarin monitors via INR.
Master these connections—dolichol links glycosylation to ER stress; vitamin K/warfarin balance controls 90% of clinical anticoagulation.
