Q97. Match the autoimmune diseases in Column I for self-antigens in Column II
| Column I | Column II |
|---|---|
| P. Rheumatoid arthritis | (i) Myelin tissue |
| Q. Myasthenia gravis | (ii) DNA tissue |
| R. Multiple sclerosis | (iii) Acetylcholine receptors |
(A) P-(ii), Q-(iii), R-(i)
(B) P-(iii), Q-(ii), R-(i)
(C) P-(i), Q-(ii), R-(iii)
(D) P-(ii), Q-(i), R-(iii)
The correct answer is (A) P-(ii), Q-(iii), R-(i).
Disease-Antigen Matching
Rheumatoid arthritis (P) targets DNA tissue (ii), as seen in associations with anti-nuclear antibodies and rheumatoid factors reacting to modified self-proteins often linked to nuclear components in simplified CSIR NET contexts. Myasthenia gravis (Q) involves autoantibodies against acetylcholine receptors (iii), disrupting neuromuscular transmission. Multiple sclerosis (R) features immune attack on myelin tissue (i), leading to demyelination via T and B cell responses.
Option Analysis
Option (A) correctly pairs P with DNA (ii), Q with acetylcholine receptors (iii), and R with myelin (i), aligning with standard matches in exam questions where RA links to DNA via autoantibodies like those in SLE overlaps.
Option (B) incorrectly assigns P to acetylcholine receptors (iii, Myasthenia gravis antigen), Q to DNA (ii), and R to myelin (i).
Option (C) wrongly matches P to myelin (i, MS antigen), Q to DNA (ii), and R to acetylcholine receptors (iii).
Option (D) mispairs P to DNA (ii), Q to myelin (i), and R to acetylcholine receptors (iii).
Rheumatoid arthritis, Myasthenia gravis, and Multiple sclerosis represent key autoimmune diseases tested in CSIR NET Life Sciences, particularly in matching self-antigens like DNA tissue, acetylcholine receptors, and myelin tissue.
Core Self-Antigens
In rheumatoid arthritis, autoantibodies target modified proteins in synovial tissues, with exam contexts linking to DNA tissue due to rheumatoid factor and anti-citrullinated associations resembling nuclear antigens. Myasthenia gravis specifically attacks acetylcholine receptors at neuromuscular junctions, causing muscle weakness via antibody-mediated blockade. Multiple sclerosis involves myelin tissue destruction, driven by T cells and antibodies against myelin oligodendrocyte glycoprotein and basic protein.
CSIR NET Matching Strategy
For questions like Q97, memorize: RA-DNA (ii), MG-AChR (iii), MS-myelin (i), selecting option (A). Incorrect options swap antigens, testing precise recall of organ-specific autoimmunity.
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RA: Joint inflammation from synovial autoantigens
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MG: Neuromuscular failure from receptor antibodies
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MS: CNS demyelination from myelin attack
