Category: CSIR NET Life Science Previous Year Questions and Solution CELL SIGNALING

69. The extracellular domain of a cell surface receptor (A) was switched with the extracellular domain of another receptor (B) to create a chimeric receptor (B-A). Assuming that there is […]

64. Binding of a ligand to a cell-surface receptor activates an intracellular signal transduction pathway through the sequential activation of four protein kinases. In the human cell line A, these […]

63. A ligand recognizes two different cell surface receptors. A and B, on the same cell type. Receptor A. after with the ligand internalized along with the ligand whereas receptor […]

62. Cultured animal cells were transfected with expression vector encoding either ß-galactosidase (β-gal) alone or expressing a fusion protein of β-gal and glucocorticoid receptor (GR). After transfection. cells were kept […]

61. A pharmacy student designed a drug to specifically target the receptors for retinoic acid in order to prevent stem cell differentiation. After in vitro trial, the investigator found that […]

60. Based on the structural regions of a nuclear receptorshown in the diagram, the following predictions weremade. A) Region F is responsible for binding to ligands and contains two zinc […]

59. Which one of the following state about the nuclear receptor super family is NOT true? (1) The receptors are always cytosol where they remain associated with heat-shock proteins and […]

58. Heat shock protein binding region is located in which one of the following domains of glucocorticoid receptor protein? (1) DNA-binding       (2) Ligand-binding (3) N-terminal         (4) Hinge region Heat Shock […]

57 Two steroid hormone receptors and Y both contain a ligand binding domain recombinant DNA technology, a modified hybrid receptor H is prepared such that it contains the ligand binding […]