13. In which cancer treatment monoclonal antibodies against erb-B2 receptor are used?
    (1) Breast (2) Oral
    (3) Prostrate  (4) Lung

The monoclonal antibodies against the erb-B2 receptor (also known as HER2 receptor) are used primarily in the treatment of:

(1) Breast cancer

Explanation:

The erb-B2 receptor or HER2 (Human Epidermal growth factor Receptor 2) is overexpressed in approximately 20-25% of breast cancers, characterized as HER2-positive breast cancer. Monoclonal antibodies like trastuzumab (Herceptin) specifically target this receptor to inhibit tumor growth by blocking HER2 signaling and engaging the immune system to attack the cancer cells. Other anti-HER2 monoclonal antibodies include pertuzumab and margetuximab, which are also used in various HER2-positive breast cancer treatment protocols. These therapies significantly improved outcomes for patients with HER2-positive breast cancer and are a standard of care.​