92. Match the components of List I with List II
List I                                                         List II
A. Sequence alignment                     I. PUBMED
B. Structural alignment                   II. BLAST
C. Fold prediction                              III. ROSETTA
D. Review of literature                     IV. DALI
Choose the correct answer from the options given below:
(a) A-I, B-IV, C-III, D-II
(b) A-II, B-III, C-IV, D-I
(c) A-II, B-III, C-IV, D-I
(d) A-II, B-IV, C-III, D-I

Correct Answer:

(d) A-II, B-IV, C-III, D-I

Explanation:

Matching Components:

• A. Sequence Alignment: Sequence alignment is commonly associated with the BLAST tool (II). BLAST (Basic Local Alignment Search Tool) is one of the most widely used tools for sequence alignment. It allows researchers to compare nucleotide or protein sequences to databases of known sequences to identify similarities.

• B. Structural Alignment: Structural alignment is used to compare the three-dimensional structures of proteins. This task is typically associated with DALI (IV). DALI is a tool that aligns protein structures based on their three-dimensional folds and is used for structural comparison.

• C. Fold Prediction: This task involves predicting the three-dimensional structure or “fold” of a protein from its sequence. ROSETTA (III) is a well-known software suite used for protein structure prediction and design, making it the correct match for fold prediction.

• D. Review of Literature: A review of literature in the context of bioinformatics and scientific research is generally found in PUBMED (I). PubMed is a comprehensive database of biomedical literature, including journal articles, research papers, and reviews.

Why Other Options Are Incorrect:

• (a) A-I, B-IV, C-III, D-II: This is incorrect because Sequence alignment (A) is more related to BLAST (II), not PUBMED (I).

• (b) A-II, B-III, C-IV, D-I: This is incorrect because Structural alignment (B) is more correctly associated with DALI (IV), not ROSETTA (III).

• (c) A-II, B-III, C-IV, D-I: This is incorrect because Fold prediction (C) is associated with ROSETTA (III), not DALI (IV).

Conclusion:

The correct answer is (d), where:

• A (Sequence Alignment) is matched with II (BLAST),

• B (Structural Alignment) is matched with IV (DALI),

• C (Fold Prediction) is matched with III (ROSETTA), and

• D (Review of Literature) is matched with I (PUBMED).