- Glucose-1-P level can increase in liver cell due to
(1) Increased glycogen breakdown
(2) Reduced glycogenesis
(3) Both
(4) Increased glycolysisWhat Is Glucose-1-Phosphate?
Glucose-1-phosphate is a phosphorylated sugar that serves as a key intermediate in glycogen metabolism. It is produced during glycogenolysis—the breakdown of glycogen—and can be converted to glucose-6-phosphate (Glc-6-P), which enters glycolysis or gluconeogenesis pathways depending on cellular needs.
In liver cells, Glc-6-P can be dephosphorylated by glucose-6-phosphatase to free glucose, which is then released into the bloodstream to maintain blood glucose levels.
How Does Glycogen Breakdown Increase Glucose-1-Phosphate?
Glycogen breakdown (glycogenolysis) is initiated by the enzyme glycogen phosphorylase, which cleaves glucose residues from glycogen as glucose-1-phosphate molecules.
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Increased Glycogenolysis:
When glycogen breakdown is upregulated, more glucose-1-phosphate is released from glycogen stores, leading to elevated intracellular Glc-1-P levels. -
Hormonal Regulation:
Hormones like glucagon and epinephrine activate glycogen phosphorylase via signaling cascades involving protein kinase A (PKA), stimulating glycogenolysis during fasting or stress.
How Does Reduced Glycogenesis Affect Glucose-1-Phosphate Levels?
Glycogenesis is the process of synthesizing glycogen from glucose, primarily involving the enzyme glycogen synthase.
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Reduced Glycogenesis:
When glycogen synthesis is downregulated, less glucose-1-phosphate is utilized to form glycogen, causing Glc-1-P to accumulate. -
Regulatory Mechanisms:
Phosphorylation of glycogen synthase by PKA inactivates the enzyme, decreasing glycogenesis during conditions requiring glucose mobilization.
Can Both Increased Glycogen Breakdown and Reduced Glycogenesis Increase Glucose-1-Phosphate?
Yes, both processes contribute to elevated Glc-1-P levels:
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Increased glycogenolysis releases more Glc-1-P from glycogen.
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Reduced glycogenesis decreases the consumption of Glc-1-P for glycogen synthesis.
Thus, either or both can raise Glc-1-P concentrations in liver cells.
Why Is Increased Glycolysis Not a Cause?
Glycolysis primarily consumes glucose-6-phosphate, not glucose-1-phosphate directly. Therefore, increased glycolysis does not lead to accumulation of Glc-1-P.
Summary Table
Option Effect on Glucose-1-Phosphate Level Explanation (1) Increased glycogen breakdown Increases More Glc-1-P released from glycogen (2) Reduced glycogenesis Increases Less Glc-1-P used for glycogen synthesis (3) Both Increases Combined effect of (1) and (2) (4) Increased glycolysis No significant effect Glycolysis consumes Glc-6-P, not Glc-1-P Conclusion
Glucose-1-phosphate levels in liver cells can increase due to both increased glycogen breakdown and reduced glycogenesis. These processes regulate the balance between glucose storage and release, enabling the liver to maintain blood glucose homeostasis effectively.
Correct answer: (3) Both
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25 Comments
Kirti Agarwal
September 18, 2025Increase glycogen breakdown and reduce gluconiogenesis
Neha Yadav
September 20, 2025G-1-P level increase in liver due to increase glycogen breakdown and reduced glycogensis
Bhawna Choudhary
September 21, 2025both increased glycogen breakdown and reduced glycogenesis
Sonal Nagar
September 21, 2025Both
Increased glycogen breakdown
And Reduced glycogenesis
Manisha choudhary
September 22, 2025Glycogen breakdown jyada hoga too glu-1 -P kaa level bdhega
Glycogenesis km hoga means Glucose s glycogen bnana too glu-1P kaa use km hoga so glu-1P ki concentration bdhegi
3option is right
Pallavi Ghangas
September 22, 2025glycogen breakdown and reduce glycogenesis
Aakansha sharma Sharma
September 22, 2025both increased glycogen breakdown and reduced glycogenesis
Aafreen Khan
September 23, 2025G-1P level increase in liver due to both.
increase glycogen breakdown and reduced glycogensis
Dharmpal Swami
September 23, 2025G1P in liver cell increase glycogen breakdown and reduced glycogensis
Anurag Giri
September 23, 2025Glucose-1-phosphate levels in liver cells can increase due to both increased glycogen breakdown and reduced glycogenesis. These processes regulate the balance between glucose storage and release, enabling the liver to maintain blood glucose homeostasis effectively.
Heena Mahlawat
September 24, 2025Increases by increasing glucogenolysis and reduced glycogenesis
Roopal Sharma
September 24, 2025Reduced glycogen synthesis led to less consumption of glycogen and increase in glycogenolysis led to more formation glucose 1 phosphate so both options are correct .
Minal Sethi
September 24, 20251.Increased glycogen breakdown will give rise to more Glc-1-P released from glycogen
2.Reduced glycogenesis will accumulate more Glc-1-P
Both option c
Nilofar Khan
September 24, 2025Correct answer is (3) both
G1P level can increase in liver cell due to Increased glycogen breakdown and Reduced glycogenesis ( glycogenolysis)
Deepika sheoran
September 24, 2025Option C is correct answer
Because both increased glycogen break down and reduced glycogenesis.
Soniya Shekhawat
September 24, 2025Glucose one phosphate in liver cells is increased during the glycogen breakdown and reduce of glycogenesis to maintain the homeostatic in blood glucose .
Mohd juber Ali
September 24, 2025Glucose1p levels in liver cells can increase due to both( increased glycogen breakdown and reduced glycogenesis)
Payal Gaur
September 25, 2025Both increase glycogen breakdown and reduce glycogenesis
Kavita Choudhary
September 25, 2025Glucose 1 phosphate level in liver cell increase due to increased glycogen and breakdown and reduse glyoniogenais so both are right answer
Avni
September 25, 2025Glucose-1-phosphate levels in liver cells can increase due to both increased glycogen breakdown and reduced glycogenesis
Muskan Yadav
September 26, 2025Glucose-1-phosphate levels in liver cells can increase due to both increased glycogen breakdown and reduced glycogenesis.
Arushi Saini
September 27, 2025both increased glycogen breakdown and reduced glycogenesis
Kajal
October 2, 2025Option 3both
Santosh Saini
October 5, 2025Glucose 1 phosphate level can increase in liver cell due to increased glycogen breakdown and reduced glycogenesis
Sakshi Kanwar
November 26, 2025both increased glycogen breakdown and reduced glycogenesis.