32. In human males, autosomal and sex trisomy mains occurs due to- (1) Error in meiosis (2) Non-disjunction of chromosome (3) Dominant Y chromosome (4) Faulty Repair mechanism

32. In human males, autosomal and sex trisomy mains occurs due to-
(1) Error in meiosis
(2) Non-disjunction of chromosome
(3) Dominant Y chromosome
(4) Faulty Repair mechanism

Option-wise explanation

  1. Error in meiosis

  • Too vague. Trisomy is a very specific kind of meiotic error: failure of chromosomes to separate. Many different “errors in meiosis” exist, but the textbook term for trisomy origin is nondisjunction.

  1. Non-disjunction of chromosome – correct

  • Trisomy occurs when a pair of homologous chromosomes (meiosis I) or sister chromatids (meiosis II) fails to separate, so one gamete gets two copies and the other gets none.

  • Fusion of such an n+1 gamete with a normal n gamete produces a 2n+1 zygote (autosomal or sex-chromosome trisomy).

  1. Dominant Y chromosome

  • The Y chromosome carries male-determining genes (like SRY) but is not “dominant” in a way that explains trisomy. It does not cause an extra copy of any chromosome.

  1. Faulty repair mechanism

  • DNA repair defects can cause mutations or structural rearrangements, but numerical chromosome abnormalities like trisomy are specifically due to mis-segregation (nondisjunction), not repair failure.

So, autosomal and sex-chromosome trisomies in human males mainly result from chromosomal non-disjunction (option 2).

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