199. Which one of the following is a valid assumption regarding the molecular clock hypothesis in evolution? (1) For a given protein sequence, mutations accumulate at a constant rate in […]
Tag: dbt jrf 2019
Tag: dbt jrf 2019
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Key Assumptions of the PAM Matrix in Evolutionary Biology: Understanding What Doesn’t Belong
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- April 13, 2025
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198. Which one of the following is NOT an assumption of an evolutionary model of the PAM matrix? (1) Probability of a mutation at one position of a sequence is […]
Interpreting Multiple Sequence Alignments: Understanding Regions of Insertions and Deletions
192. In a multiple sequence alignment of homologous protein sequences, a region of multiple insertions and deletions indicates the presence of: (1) a secondary structure element (2) a buried region […]
Understanding Different Types of BLAST Programs for Sequence Search Tasks
191. Match the type of BLAST programs given in Group I to the particular type of sequence search task described in Group II Group I Group II 1 tblastn P […]
Understanding Analogs, Paralogs, Orthologs, and Xenologs in Evolution
190. Genes or proteins that display the same activity, but have different origins and are the product of convergent evolution, are called: (1) Analogs (2) Paralogs (3) Orthologs (4) Xenologs […]
Title: Understanding Sensitivity and Specificity in Homologous Database Searches
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- April 13, 2025
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188. Match the items in Group I with Group II with reference to a database search for identifying homologs of human hemoglobin. Group I Group II (P) Sensitivity (1) Measure […]
Gene Set Enrichment Analysis (GSEA) and the Role of Gene Ontology
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- April 13, 2025
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186. For Gene Set Enrichment Analysis (GSEA), differentially expressed genes are grouped into broader functions. A typical tool/resource used for this purpose is: (1) Gene Ontology (2) BLAST against the […]
Title: The Most Accurate Method for Rescoring Docked Ligand-Protein Complexes in Molecular Docking
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- April 13, 2025
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183. Which one of the following methods is most accurate in rescoring docked ligandprotein complexes? (1) Molecular mechanics non-bonded energy functions (2) Binding free energy calculations incorporating solvation models (3) […]
Title: Exploring the Use of Sequence Profiles to Mine Related Sequences from TrEMBL
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- April 13, 2025
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181. A representative sequence profile of a given nucleotide binding domain is to be used to mine related sequences from TrEMBL. The database to be used to extract the query […]
Title: Understanding the Role of Methanosarcina and Bacillus in Anaerobic Glucose Fermentation
180. An anaerobic flask containing 50 ml of media with glucose as the sole carbon source was inoculated with a consortium consisting of Methanosarcina and Bacillus. After two weeks of […]


