40. Prostate cancer cells were treated with Drug A and Drug B in order to check the efficacy of the drugs in arresting the growth of cells. The following results were obtained:

Which one of the following statements is NOT correct?
(1) Drug A targets the Wnt signaling pathway but does not lead to death of cells
(2) Drug B targets the Wnt signaling pathway and leads to G₁ cell cycle arrest.
(3) Both drugs A and B lead to cell death but targets different apoptotic pathways.
(4) Drug A kills cells via the mitochondrial-independent pathway.

The statement that is NOT correct based on the information about Drug A and Drug B effects on prostate cancer cells targeting the Wnt signaling pathway is:

(3) Both drugs A and B lead to cell death but target different apoptotic pathways.

Explanation:

• Drug A targets the Wnt signaling pathway but does not lead to cell death; it may affect proliferation or survival pathways without inducing apoptosis directly.

• Drug B targets the Wnt signaling pathway and leads to G1 cell cycle arrest, effectively halting cell proliferation.

• Drug A kills cells via the mitochondrial-independent pathway, consistent with apoptosis through the extrinsic or alternative pathways.

• Since Drug A does not cause death via the Wnt pathway but through a mitochondrial-independent pathway, and Drug B induces cell cycle arrest rather than death, the statement that both lead to cell death via different apoptotic pathways is incorrect.