Tag: DNA REPLICATION CSIR NET PYQ

The followjng statements are made with reference to the replication of DNA. The eukaryotic counterpart of the bacterial B- clamp protein is proliferating cell nuclear antigen (PCNA) Mutation inactivating one […]

Which one of the following proteins is essential for both the initiation of DNA replication as well as the continued advance of the replication fork? (1) ORC        (2) Geminin (3) […]

E. coli DNA ligase catalyses formation of a phosphodiester bond between the adjoining 3′ hydroxyl, and the 5′ phosphoryl ends in DNA duplexes. The energetic need for this reaction is […]

In eukaryotes shortening of chromosomes from ends is prevented bv (1) DNA polymerase     (2) RNA polymerase (3) Telomerase           (4) Transposase   Introduction Eukaryotic chromosomes are linear structures with ends known […]

54 In eukaryotic replication, priming of DNA synthesis and removal of RNA catalyzed by (1) DNAPol α and PCNA, respectively (2) DNA Pol α and FEN 1, respectively (3) DNA […]

In a human cell line, a large fraction of double-strand DNA breaks are repaired by non-homologous end joining (NHEJ). An inhibitor of FLAP endonuclease will affect (1) recruitment of DNA—dependent […]

In prokaryotes during replication, the lagging strand is synthesized in a series of short fragments known as Okazaki fragments, consequently requiring many primers. The RNA primers of Okazaki fragments are […]

During replication, RNaseH removes all of the RNA primer except the ribonucleotide directly linked to the DNA end. This is because (1) it can degrade RNA and DNA end. From […]

The following statements refer to factors regulating the fidelity of DNA replication. The 5′ to 3′ exonuclease activity of the replicative DNA polymerase. Imbalanced intracellular concentrations of the four dNTPs. […]

49. A mutant DNA polymerase was found to have higher error rate and synthesized only short DNA fragments. In the statements below, potential explanations are given. A. The 5′ to […]