143. A sample genetic code is given below: If an amino acid substitution matrix based on genetic code is derived for sequence alignment and analysis from evolutionary studies, which one […]
Tag: dbt jrf 2018
Tag: dbt jrf 2018
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Identifying the Highest-Scoring Alignment in Sequences: A Guide to Alignment Algorithms
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- April 14, 2025
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142. Two sequences of comparable length have several regions that align locally, but are separated by other regions that align poorly. Which algorithm can be used to find the highest-scoring […]
Understanding the GenBank Sequence Entry Format
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- April 14, 2025
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Question Which one of the following is a depiction of the GenBank sequence entry format? >YCZ2_YEAST protein in HMR 3′ region MKAVVIEDGKAVVKEGVPIPELEEGFVGNPTDWAHIDYKVGPQSILGCDAAGQG* BASE COUNT 215 A 224 G 263 G […]
Identifying AMP Binding Proteins Using PROSITE Motif Pattern
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- April 14, 2025
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138. The PROSITE pattern representing the conserved sequence motif for a new family of AMP binding protein is [LIVMFY]-X(2)-[STG]-[STAG]-G-[ST]. You are given a sequence of a 15-amino acid stretch starting […]
Measuring Similarity Between Predicted and Experimental Protein Structures: A Guide
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- April 14, 2025
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137. Which one of the following can be used to measure the extent of similarity between the predicted structure of a protein and its experimentally determined structure? 1. Root mean […]
Protein Structure Prediction: Understanding Energy Minimization in Conformational Space
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- April 14, 2025
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136. Which one of the following protein structure prediction methods is based on the principle of locating lowest energy minimum in the conformation space of a protein? 1. Ab initio […]
Understanding Peptide Conformations and Their End-to-End Distances
135. X, Y and Z correspond to three different conformers of an 18-residue peptide, where X: α helix, Y: β strand and Z: 310 helix. Which of the following correspond […]
Understanding Energy Components in Molecular Mechanics Forcefields for Protein Structures
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- April 14, 2025
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134. If the energy of a protein structure is calculated using molecular mechanics forcefield, which of the following energy components CANNOT have a negative value? 1. Bond energy 2. Dihedral […]
Understanding the Maximum and Minimum Conformations of Amino Acids in the Ramachandran Plot
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- April 14, 2025
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133. Which of the following corresponds to the amino acid pair having maximum and minimum number of allowed conformations in the Ramachandran plot? 1. Max: Gly, Min: Pro 2. Max: […]
Understanding the Cis-Peptide Unit and Its Dihedral Angle in Protein Structure
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- April 14, 2025
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132. Cis-peptide unit corresponds to the O-C-N-H dihedral angle (degrees) of: 1. 0 2. -60 3. 120 4. 180 Question Cis-peptide unit corresponds to the O-C-N-H dihedral angle (degrees) of: […]


