MECHANISMS OF OXIDATIVE PHOSPHORYLATION SHUTTLE SYSTEM

MECHANISMS OF OXIDATIVE PHOSPHORYLATION SHUTTLE SYSTEM

16.6.      Shuttle system :

The glycerophosphate shuttle. The electrons of cytosolic NADH are transported to the mitochondrial electron-transport chain in three steps : (1) Cytosolic oxidation of NADH by dihydroxyacetone phosphate catalyzed by glycerol-3-phosphate dehydrogenase.

This enzyme is present in cytosolic (2) Oxidation of glycerol-3-phosphate by flavoprotein dehydrogenase with the reduction of FAD to FADH2. (3) Reoxidation of FADH2 with the passage of electrons into the electron-transport chain.


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